BioSocieties

, Volume 5, Issue 1, pp 89–104 | Cite as

Toward a critical neuroscience of ‘addiction’

  • Nancy D Campbell
Original Article

Abstract

Early to mid-twentieth century studies on the neurophysiology of the role of conditioned cues in relapse, conducted at the Addiction Research Center in Lexington, Kentucky, were the historical antecedents to today's neuroimaging studies. Attempts in the 1940s to see ‘what's going on in the brains of these addicts’ were formative for the field, as was foundational work done in the 1940s and 1950s by Abraham Wikler on conditioned cues, the role of what he called the ‘limbic system’ in relapse, and possible uses of narcotic antagonists to prevent relapse by extinguishing cues. This article sketches the historical context in order to situate continuities between historical antecedents and a current ethnographic case study focused on current neuroimaging studies of the role of ‘craving’ – and neural processes that precede conscious ‘craving’ and occur ‘outside awareness’ – in relapse conducted by Anna Rose Childress at the Treatment Research Center in Philadelphia, Pennsylvania. The article showcases the incommensurability between claims that ‘addiction’ is a matter of individual choice, and claims that it is a neurochemical disorder disruptive of volition. Neuroscientists offer scientific vocabulary and imagery that both shape and respond to the social experience of addiction. The conclusion considers the value of moving toward a critical neuroscience more cognizant of the social worlds in which ‘addiction’ occurs, not in the restricted sense of ‘social factors’ but through awareness of the social–situational contexts and relationships within which ‘addictions’ are experienced and studied.

Keywords

addiction history neuroimaging neuroscience science and technology studies 

References

  1. Acker, C. (2002) Creating the American Junkie: Addiction Research in the Classic Era of Narcotics Control. Baltimore, MD: Johns Hopkins University Press.Google Scholar
  2. Andrews, H.L. (1941) Brain potentials and morphine addiction. Psychosomatic Medicine 3: 399–409.CrossRefGoogle Scholar
  3. Andrews, H.L. (1978) Comments on electroencephalographic and sleep studies. In: W.R. Martin and H. Isbell (eds.) Drug Addiction and the US Public Health Service. Rockville, MD: US Department of Health, Education, and Welfare, pp. 152–154.Google Scholar
  4. Campbell, N.D. (2007) Discovering Addiction: The Science and Politics of Substance Abuse Research. Ann Arbor. MI: University of Michigan Press.CrossRefGoogle Scholar
  5. Campbell, N.D., Olsen, J.P. and Walden, L. (2008) The Narcotic Farm: The Rise and Fall of America's First Prison for Drug Addicts. New York: Harry N. Abrams.Google Scholar
  6. Cetina, K.K. (2001) Epistemic Cultures: How the Sciences Make Knowledge. Cambridge, MA: Harvard University Press.Google Scholar
  7. Childress, A.R. et al (2008) Prelude to passion: Limbic activation by ‘unseen’ drug and sexual cues. PLoS ONE 3 (1): e1506. doi:10.1371/journal.pone.0001506.CrossRefGoogle Scholar
  8. Childress, A.R., Mozley, P.D., McElgin, W., Fitzgerald, J., Reivich, M. and O'Brien, C.P. (1999) Limbic activation during cue-induced cocaine craving. American Journal of Psychiatry 156: 11–18.CrossRefGoogle Scholar
  9. Choudhury, S., Nagel, S.K. and Slaby, J. (2009) Critical neuroscience: Linking science and society through critical practice. BioSocieties 4 (2009): 61–77.CrossRefGoogle Scholar
  10. Cohn, S. (2008) Petty cash and the neuroscientific mapping of pleasure. BioSocieties 3: 151–163.CrossRefGoogle Scholar
  11. Dumit, J. (2002) Picturing Personhood: Brain Scans and Biomedical Identity. Princeton, NJ: Princeton University Press.Google Scholar
  12. DuPont, R.L. (1997) The Selfish Brain: Learning from Addiction. Washington DC: American Psychiatric Press.Google Scholar
  13. Everitt, B.J. and Robbins, T.W. (1992) Amygdala-ventral striatal interactions and reward-related processes. In: J.P. Aggleton (ed.) The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction. New York: Wiley-Liss, pp. 401–429.Google Scholar
  14. Freud, S. (1961) Beyond the Pleasure Principle, Translated by J. Strachey. New York: W. W. Norton.Google Scholar
  15. Freud, S. (1975) Three Essays on the Theory of Sexuality, Translated by J. Strachey. New York: Basic Books.Google Scholar
  16. Galison, P.L. and Stump, D.J. (1996) The Disunity of Science. Palo Alto, CA: Stanford University Press.Google Scholar
  17. Gieryn, T.F. (1999) Cultural Boundaries of Science: Credibility on the Line. Chicago, IL: University of Chicago Press.Google Scholar
  18. Gilbert, N. and Mulkay, M. (1984) Opening Pandora's Box: A Sociologists’ Analysis of Scientists’ Discourse. Cambridge: Cambridge University Press.Google Scholar
  19. Glantz, M. and Pickens, R.W. (1992) Vulnerability to Drug Abuse. Washington DC: American Psychological Association.CrossRefGoogle Scholar
  20. Hyman, S.E. and Malenka, R.C. (2001) Addiction and the brain: The neurobiology of compulsion and its persistence. Nature Reviews Neuroscience 2: 695–703.CrossRefGoogle Scholar
  21. Jaffe, J.H. (1965) Drug addiction and drug abuse. In: L. Goodman and A.G. Gilman (eds.) The Pharmacological Basis of Therapeutics, 3rd edn. New York: Macmillan.Google Scholar
  22. Keane, H. and Hamill, K. (2010) Variation in addiction: The molecular and the molar in neuroscience and pain medicine. BioSocieties 5(1): 52–69.CrossRefGoogle Scholar
  23. Keller, E.F. (1992) Secrets of Life, Secrets of Death. New York: Routledge.Google Scholar
  24. Koob, G.F. and Le Moal, M. (2006) Neurobiology of Addiction. New York: Elsevier.Google Scholar
  25. Kushner, H.I. (2006) Taking biology seriously: The next task for historians of addiction? Bulletin of the History of Medicine 80: 115–143.CrossRefGoogle Scholar
  26. Latour, B. and Woolgar, S. (1986) Laboratory Life: The Construction of Scientific Facts, 2nd edn. Princeton, NJ: Princeton University Press.Google Scholar
  27. Martin, W.R. and Isbell, H. (eds.) (1978) Drug Addiction and the US Public Health Service. Rockville, MD: US Department of Health, Education, and Welfare.Google Scholar
  28. McIntire, T.R. (2008) A Retrospective survey of the career of Abraham Wikler: Implications for the understanding and treatment of drug addiction in America today. Master's thesis, Boston University School of Medicine.Google Scholar
  29. Moyers, W.C. and Ketchum, K. (2006) Broken: My Story of Addiction and Redemption. New York: Penguin.Google Scholar
  30. Rose, N. (2003) Becoming neurochemical selves. In: N. Stehr (ed.) Biotechnology Between Commerce and Civil Society. New Brunswick, NJ: Transaction, pp. 1–43.Google Scholar
  31. Smith, D.E. (1999) Writing the Social: Critique, Theory, and Investigations. Toronto, Canada: University of Toronto Press.Google Scholar
  32. Volkow, N. and Li, T.K. (2004) Drug addiction: The neurobiology of behavior gone awry. Nature Reviews: Neuroscience 12: 963–970.CrossRefGoogle Scholar
  33. Volkow, N. and Li, T.K. (2005) The neuroscience of addiction. Nature Neuroscience 8: 1429–1430.CrossRefGoogle Scholar
  34. Vrecko, S. (2010) Civilizing technologies and the control of deviance. BioSocieties 5 (1): 36–51.CrossRefGoogle Scholar
  35. Wikler, A. (1948) Recent progress in research on the neurophysiologic basis of morphine addiction. American Journal of Psychiatry 105 (5): 329–338.CrossRefGoogle Scholar
  36. Wikler, A. (1950) Sites and mechanisms of action of morphine and related drugs in the central nervous system. Part II. Journal of Pharmacology and Experimental Therapeutics 3 (3): 436–506.Google Scholar
  37. Wikler, A. (1952) A psychodynamic study of a patient during experimental self-regulated readdiction to morphine. Psychiatric Quarterly 26: 279–293.CrossRefGoogle Scholar
  38. Wikler, A. (1957) The Relation of Psychiatry to Pharmacology. Baltimore, MD: Williams and Wilkins.Google Scholar
  39. Wikler, A. (1965) Conditioning factors in opiate addiction and relapse. In: D.M. Wilner and G.G. Kassebaum (eds.) Narcotics. New York: McGraw-Hill.Google Scholar
  40. Wikler, A. (1974) The search for the psyche in drug dependence. Nathan B. Eddy Memorial Award Lecture. Annual meeting of the College of Problems of Drug Dependence.Google Scholar
  41. Wikler, A. (1977) Methadone maintenance and narcotic blocking drugs. International Journal of the Addictions 12 (7): 869–881.CrossRefGoogle Scholar
  42. Wikler, A., Norrell, H. and Miller, D. (1972) Limbic system and opioid addiction in the rat. Experimental Neurology 34 (3): 543–557.CrossRefGoogle Scholar
  43. Wikler, A., Pescor, M.J., Kalbaugh, E.P. and Angelucci, R.J. (1952) Effects of frontal lobotomy on the morphine-abstinence syndrome in man: An experimental study. A.M.A. Archives of Neurology and Psychiatry 67 (4): 510–521.CrossRefGoogle Scholar

Copyright information

© The London School of Economics and Political Science 2010

Authors and Affiliations

  • Nancy D Campbell
    • 1
  1. 1.Department of Science and Technology StudiesSage Labs 5508, Rensselaer Polytechnic InstituteNew YorkUSA

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