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BioSocieties

, Volume 5, Issue 1, pp 153–156 | Cite as

Ethics of neuroenhancement: A phantom debate

  • Boris B Quednow
Books Forum

BettinaSchöne-Seifert, DaviniaTalbot, UweOpolka and Johann SAch (eds.), Neuro-Enhancement. Ethik vor neuen Herausforderungen, Paderborn: mentis, 2009, £33.38, ISBN: 978-3-89785-602-8.

With their book Neuro-Enhancement: Ethik vor neuen Herausforderungen, the editors Bettina Schöne-Seifert, Davinia Talbot, Uwe Opolka, and Johann S. Ach have delivered a collection of articles providing a cross-section of the ongoing debate over cognitive and mood enhancement in Germany. As a pharmacopsychologist working on the neurochemistry of cognition and emotion I have followed this debate for several years now and I have felt uneasy about it from the start. What follows might rather be a perspectival response to the presented volume than a classical book review. But considering the current proliferation of publications on the ethics of neuroenhancement it seems about time to call into question some of the pharmacological and epidemiological presumptions on which this emergent body of literature –...

References

  1. Arnsten, A.F. and Li, B.M. (2005) Neurobiology of executive functions: Catecholamine influences on prefrontal cortical functions. Biological Psychiatry 57 (11): 1377–1384.CrossRefGoogle Scholar
  2. Berridge, K.C. (2007) The debate over dopamine's role in reward: The case for incentive salience. Psychopharmacology (Berl) 191 (3): 391–431.CrossRefGoogle Scholar
  3. Clatworthy, P.L. et al. (2009) Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory. Journal of Neuroscience 29 (15): 4690–4696.CrossRefGoogle Scholar
  4. DAK. (2009) Gesundheitsreport 2009: Analyse der Arbeitsunfähigkeitsdaten. Schwerpunktthema Doping am Arbeitsplatz. Hamburg: DAK Forschung.Google Scholar
  5. de Jongh, R., Bolt, I., Schermer, M. and Olivier, B. (2008) Botox for the brain: Enhancement of cognition, mood and pro-social behavior and blunting of unwanted memories. Neuroscience & Biobehavioral Reviews 32 (4): 760–776.CrossRefGoogle Scholar
  6. Johnston, L.D., O'Malley, P.M., Bachman, J.G. and Schulenberg, J.E. (2005) Monitoring the Future National Survey Results on Drug Use, 1975–2004. Volume I and II: Secondary School Students and College Students and Adults Ages 19–45. Bethesda, MD: National Institute on Drug Abuse (NIH Publication Nos. 05-5727 and 05-5728).Google Scholar
  7. Kahneman, D. (1973) Attention and Effort. Englewood Cliffs, NJ: Prentice-Hall.Google Scholar
  8. Kapner, D.A. (2003) Recreational Use of Ritalin on College Campuses. Newton, MA: The Higher Education Center for Alcohol and Other Drug Prevention.Google Scholar
  9. Kapner, D.A. (2008) Recreational Use of Ritalin on College Campuses. Newton, MA: The Higher Education Center for Alcohol and Other Drug Prevention.Google Scholar
  10. Killgore, W.D., Rupp, T.L., Grugle, N.L., Reichardt, R.M., Lipizzi, E.L. and Balkin, T.J. (2008) Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44h of continuous wakefulness. Journal of Sleep Research 17 (3): 309–321.CrossRefGoogle Scholar
  11. Kumar, R. (2008) Approved and investigational uses of modafinil: An evidence-based review. Drugs 68 (13): 1803–1839.CrossRefGoogle Scholar
  12. Lanni, C. et al. (2008) Cognition enhancers between treating and doping the mind. Pharmacological Research 57 (3): 196–213.CrossRefGoogle Scholar
  13. Mattay, V.S. et al. (2000) Effects of dextroamphetamine on cognitive performance and cortical activation. Neuroimage 12 (3): 268–275.CrossRefGoogle Scholar
  14. Mattay, V.S. et al (2003) Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proceedings of the National Academy of Sciences U S A 100 (10): 6186–6191.CrossRefGoogle Scholar
  15. McCabe, S.E., Knight, J.R., Teter, C.J. and Wechsler, H. (2005) Non-medical use of prescription stimulants among US college students: Prevalence and correlates from a national survey. Addiction 100 (1): 96–106.CrossRefGoogle Scholar
  16. Mehta, M.A., Owen, A.M., Sahakian, B.J., Mavaddat, N., Pickard, J.D. and Robbins, T.W. (2000) Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain. Journal of Neuroscience 20 (6): RC65.Google Scholar
  17. Muller, U., Steffenhagen, N., Regenthal, R. and Bublak, P. (2004) Effects of modafinil on working memory processes in humans. Psychopharmacology (Berl) 177 (1–2): 161–169.CrossRefGoogle Scholar
  18. Randall, D.C., Shneerson, J.M. and File, S.E. (2005) Cognitive effects of modafinil in student volunteers may depend on IQ. Pharmacology Biochemistry & Behavior 82 (1): 133–139.CrossRefGoogle Scholar
  19. Rasmussen, N. (2008) America's first amphetamine epidemic 1929–1971: A quantitative and qualitative retrospective with implications for the present. American Journal of Public Health 98 (6): 974–985.CrossRefGoogle Scholar
  20. Sussman, S., Pentz, M.A., Spruijt-Metz, D. and Miller, T. (2006) Misuse of ‘study drugs’: prevalence, consequences, and implications for policy. Substance Abuse Treatment, Prevention and Policy 1: 15.CrossRefGoogle Scholar
  21. Teter, C.J., McCabe, S.E., Cranford, J.A., Boyd, C.J. and Guthrie, S.K. (2005) Prevalence and motives for illicit use of prescription stimulants in an undergraduate student sample. Journal of American College Health 53 (6): 253–262.CrossRefGoogle Scholar
  22. Wesensten, N.J., Belenky, G., Kautz, M.A., Thorne, D.R., Reichardt, R.M. and Balkin, T.J. (2002) Maintaining alertness and performance during sleep deprivation: Modafinil versus caffeine. Psychopharmacology (Berl) 159 (3): 238–247.CrossRefGoogle Scholar

Copyright information

© The London School of Economics and Political Science 2010

Authors and Affiliations

  • Boris B Quednow
    • 1
  1. 1.University Hospital of Psychiatry, University of ZürichSwitzerland

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