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HLA antigens in iranian patients with B-cell chronic lymphocytic leukemia

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Pathology & Oncology Research

Abstract

The frequency of HLA class-I and class-II antigens was investigated in 32 Iranian patients with B-cell chronic lymphocytic leukemia (B-CLL), using the microlymphocytotoxicity method. A significant increase in the HLA- B13 (P<0.01) and DR53 (P < 0.05) and a significant negative association with the A11 (P < 0.05), B35 (P < 0.05), Cw3 (P < 0.05), and DR1 (P < 0.02) antigens were observed in these patients, compared to the control normal population. These results suggest involvement of some HLA antigens in the multif actorial process of predisposition to BCLL.

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Authors and Affiliations

  1. Department of Immunology, School of Medical Sciences, Tarbiat Modarres University, Tehran

    Seyed M Moazzen

  2. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, 14155-6446 LR., Tehran, Iran

    Seyed M Moazzen & Fazel Shokri

  3. Department of Immunology, Ahwaz University of Medical Sciences, Ahwaz, Iran

    Ali A Amirzargar

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  1. Seyed M Moazzen
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  2. Ali A Amirzargar
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  3. Fazel Shokri
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Moazzen, S.M., Amirzargar, A.A. & Shokri, F. HLA antigens in iranian patients with B-cell chronic lymphocytic leukemia. Pathol. Oncol. Res. 5, 142–145 (1999). https://doi.org/10.1053/paor.1999.0190

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  • DOI: https://doi.org/10.1053/paor.1999.0190

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