Abstract
Twenty cases of primary Fallopian tube endometrioid carcinoma (PFTEC) are presented in the paper. This accounts for 42.5% of all histologic forms of primary Fallopian tube carcinoma (PFTC) found in our Department. The youngest patient was 38, and the oldest 68 years (mean: 56 years). Seven patients were nulliparas. Only two cases were bilateral. According to FIGO staging, 13 cases were evaluated as stage I, 4 as II, and 3 as stage III. Due to the histologic grading, 8 tumors were classified as well, 7 as moderately, and 5 as poorly differentiated. In the time of preparation of the manuscript, 12 women were still alive, 2 of them with recurrent disease. The follow-up of patients without recurrence ranged from 4 to 120 months (median: 63). Eight patients had died (survival time: from 4 to 65 months; median: 26). Metastases were found in 8 patients, especially to ovaries. In 14/20 cases of PFTEC various forms of tubal wall invasion were observed. Blood or lymphatic vessels involvement was found in 9 patients. Six of them had died and one is alive with the symptoms of disease. Immunohistochemical detection of the mutant form of p53 protein and oncogene product, c-erbB-2, was studied in 17 cases. Nine patients exhibited simultaneous p53 protein accumulation and c-erbB-2 expression. 2/9 of these patients are alive with recurrent tumors and 4/9 died. Endometrioid carcinoma of the Fallopian tube can be characterized by a tendency to superficial invasion of tubal wall and in a half of the cases by invasion of vessels. The majority of these tumors were diagnosed at an early stage tumors.
Similar content being viewed by others
References
Barakat RR, Rubin SC, Saigo PE, et al: Cisplatin-based combination chemotherapy in carcinoma of the fallopian tube. Gynecol Oncol 42:156–160, 1991.
Benedet JL, White GW, Fairey RN, et al: Adenocarcinoma of the Fallopian tube. Experience with 41 patients. Obstet Gynecol 50:654–657, 1977.
Dembo AJ, Davy M, Stenwig AF, et al: Prognostic factors in patients with stage I epithelial ovarian cancer. Obstet Gynecol 75:263–273, 1990.
Eltabbakh GH, Belinson JL, Kennedy AW, et al: p53 overexpression is not an independent prognostic factor for patients with primary ovarian epithelial cancer. Cancer 80:892–898, 1997.
Hellstrom AC, Silfversward C, Nilsson B, et al: Carcinoma of the Fallopian tube. A clinical and histopathologic review. The Radiumhemmet series. Int J Gynecol Cancer 4:395–400, 1994.
Hu CY, Taymor ML, Hertig AT: Primary carcinoma of the Fallopian tube. Am J Obstet Gynecol 59:58–67, 1950.
Jereczek B, Jassem J, Kobierska A: Primary cancer of the Fallopian tube. Report of 26 patients. Acta Obstet Gynecol Scand 75:281–286, 1996.
Kojs Z, Urbañski K, Karolewski K, et al: Pierwotny rak jajowodu. Analiza 32 przypadków. Gin Pol 67:612–614, 1996.
Koonings PP, Campbell K, Mishell DR, et al: Relative frequency of primary ovarian neoplasms: a 10-year review. Obstet Gynecol 74:921–926, 1989.
Lacy MQ, Hartmann LC, Keeney GL, et al: c-erbB-2 and p53 expression in Fallopian tube carcinoma. Cancer 75:2891–2896, 1995.
Levesque MA, Katsaros D, Yu H, et al: Mutant p53 protein overexpression is associated with poor outcome in patients with well or moderately differentiated ovarian carcinoma. Cancer 75:1327–1338, 1995.
Lukes AS, Kohler MF, Pieper CF, et al: Multivariable analysis of DNA ploidy, p53, and HER-2/neu as prognostic factors in endometrial cancer. Cancer 73:2380–2385, 1994.
Mittal KR, Barwick KW: Diffusely infiltrating adenocarcinoma of the endometrium. A subtype with poor prognosis. Am J Surg Pathol 12:754–758, 1988.
Navani SS, Alvarado-Cabbero I, Young RH, et al: Endometrioid carcinoma of the Fallopian tube: a clinicopathologic analysis of 26 cases. Gynecol Oncol 63:371–378, 1996.
Nordin AJ: Primary carcinoma of the Fallopian tube: a 20-year literature review. Obstet Gynecol Surv 49:349–361, 1994.
Peters WA, Andersen WA, Hopkins MP, et al: Prognostic features of carcinoma of the Fallopian tube. Obstet Gynecol 71:757–762, 1988.
Poulsen HE, Taylor CW, Sobin LH: Histological typing of female genital tract tumors.WHO Geneva 1975,74–77.
Rabczyñski J, Ziókowski P, Kowalski P, et al: Primary carcinoma of the fallopian tube - clinico-morphological review of 41 cases. Med Sci Monit 1998 (in press).
Rorat E, Wallach RC: Endometrioid carcinoma of the Fallopian tube: pathology and clinical outcome. Int J Gynecol Obstet 32:163–167, 1990.
Rosen A., Klein M., Lahousen M., et al: Das primare tubenkarzinom -eine oesterreichische multizenterstudie. Geburtsh u Frauenheilk 53:321–325, 1993.
Salvesen HB, Akslen LA, Albrektsen G, et al: Poorer survival of nulliparous women with endometrial carcinoma. Cancer 82:1328–1333, 1998.
Schiller HM, Silverberg SG: Staging and prognosis in primary carcinoma of the Fallopian tube. Cancer 28:389–395, 1971.
Scully RE, Bonfiglio TA, Kurman RJ, et al: Histological typing of female genital tract tumors 2nd ed., Springer Verlag. Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong, Barcelona, Budapest, 1994, 15.
Serov SF, Scully RE, Sobin LH: International Histological Classification of Tumors, no. 9: Histological Typing of Ovarian tumors. WHO Geneva 1973.
Sedlis A: Primary carcinoma of the Fallopian tube. Obstet Gynecol Surv 16:209–226, 1961.
Tidy J, Mason WP: Endometrioid carcinoma of the ovary: a retrospective study. Brit J Obst Gynecol 95:1165–1169, 1988.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
RabczyŃski, J., ZiÖlkowski, P. Primary endometrioid carcinoma of fallopian tube. Pathol. Oncol. Res. 5, 61–66 (1999). https://doi.org/10.1053/paor.1999.0061
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1053/paor.1999.0061