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Prostatic intraepithelial neoplasia and apoptosis in benign prostatic hyperplasia before and after the chernobyl accident in Ukraine

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Pathology & Oncology Research

Abstract

The prevalence of prostatic intraepithelial neoplasia (PIN) in men who underwent surgery for benign prostatic hyperplasia (BPH) before and after the Chernobyl nuclear accident was studied. BPH samples were obtained by adenomectomy from 45 patients operated in 1984 before the accident (Group I), and 47 patients from the low contaminated Kiev City (Group II) and 76 from high contaminated area (Group III) operated between 1996 and 1998. Their BPH samples were examined histologically and immunohistochemically. The incidences of prostatic intraepithelial neoplasia (PIN) and high grade PIN (HGPIN) were 15.5 and 11.1% in Group I, 29.8 and 14.9% in Grpoup II, and 35.5 and 19.7% in Group III. The difference between the incidences of PIN in Group I and III is significant (p<0.02). There was increased apoptosis in areas of PIN in Group II and III as compared to Group I (p<0.001). Since apoptosis has been shown to be associated with ionizing radiation and it is now found to be associated with PIN in patients diagnosed after the Chernobyl nuclear accident, this suggests that long-term low dose internal ionizing radiation potentially may cause prostate cancer.

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Authors and Affiliations

  1. Departments of Pathology and Urology, Institute of Urology and Nephrology Academy of Medical Sciences of Ukraine, Kiev, Ukraine

    Alexander F Vosianov, Alina M Romanenko & Larisa B Zabarko

  2. 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Üllői út 26, 1085, Budapest, Hungary

    Béla Szende

  3. Departments of Urology and Pathology, State University of New York Health Science Center, New York, Syracuse, USA

    Ching Y Wang, Steven Landas & Gabriel P Haas

Authors
  1. Alexander F Vosianov
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  2. Alina M Romanenko
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  3. Larisa B Zabarko
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  4. Béla Szende
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  5. Ching Y Wang
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  6. Steven Landas
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  7. Gabriel P Haas
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Vosianov, A.F., Romanenko, A.M., Zabarko, L.B. et al. Prostatic intraepithelial neoplasia and apoptosis in benign prostatic hyperplasia before and after the chernobyl accident in Ukraine. Pathol. Oncol. Res. 5, 28–31 (1999). https://doi.org/10.1053/paor.1999.0028

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  • DOI: https://doi.org/10.1053/paor.1999.0028

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