Abstract
Seventy three cases of Kaposi’s sarcoma (KS) from the 3 histological subtypes (patch, plaque and nodular) were assessed for bcl-2 and p53 protein expression. The aim was to determine the level of expression of these proteins in KS and in the different subtypes. Commercially available antibodies to bcl-2 and p53 were applied after both microwave and pressure cooking antigen retrieval. Bcl-2 immunoexpression increased from the patch stage (36%) to the plaque stage (45%) to the nodular stage (70.83%). Better immunostaining for bcl-2 was obtained after pressure cooking. p53 on the other hand, was not expressed in the patch or plaque stages, but 54.16% of cases in the nodular stage were immunopositive. These results show a progression of immunoexpression of both bcl-2 and p53 from the early histological stages to the late tumor stage, implying that these proteins are upregulated late in the evolution of KS.
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Pillay, P., Chetty, R. & Reddy, R. Bcl-2 and p53 immunoprofile in kaposi’s sarcoma. Pathol. Oncol. Res. 5, 17–20 (1999). https://doi.org/10.1053/paor.1999.0017
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DOI: https://doi.org/10.1053/paor.1999.0017