Skip to main content
Log in

Utilization and dosing of angiotensin-converting enzyme inhibitors for heart failure

Effect of physician specialty and patient characteristics

  • Brief Report
  • Published:
Journal of General Internal Medicine Aims and scope Submit manuscript

Abstract

To determine if physician specialty is associated with underutilization and underdosing of angiotensin-converting enzyme inhibitors among patients with heart failure, we reviewed the charts of 214 outpatients with decreased systolic function at an urban academic medical center. Regardless of whether patients were cared for by cardiologists, generalist physicians, or a combination of the two specialties, approximately 75% of the patients were taking an angiotensin-converting enzyme inhibitor. However, only approximately 60% of these patients were taking dosages proved to be efficacious in trials. Emphasis on adequate dosing is needed among all specialty groups.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med. 1991;325:293–302.

    Article  Google Scholar 

  2. The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med. 1992;327:685–91.

    Article  Google Scholar 

  3. Pfeffer MA, Braunwald E, Moye LA, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N Engl J Med. 1992;327:669–77.

    Article  PubMed  CAS  Google Scholar 

  4. Chin MH, Goldman L. Factors contributing to the hospitalization of patients with congestive heart failure. Am J Public Health. 1997;87:643–8.

    Article  PubMed  CAS  Google Scholar 

  5. McDermott MM, Feinglass J, Sy J, Gheorghiade M. Hospitalized congestive heart failure patients with preserved versus abnormal left ventricular systolic function: clinical characteristics and drug therapy. Am J Med. 1995;99:629–35.

    Article  PubMed  CAS  Google Scholar 

  6. Philbin EF, Andreaou C, Rocco TA, Lynch LJ, Baker SL. Patterns of angiotensin-converting enzyme inhibitor use in congestive heart failure in two community hospitals. Am J Cardiol. 1996;77:832–8.

    Article  Google Scholar 

  7. Havranek EP, Graham GW, Pan Ž, Lowes B. Process and outcome of outpatient management of heart failure: a comparison of cardiologists and primary care providers. Am J Manag Care. 1996;2:783–9.

    Google Scholar 

  8. Young JB, Weiner DH, Yusuf S, et al. Patterns of medication use in patients with heart failure: a report from the Registry of Studies of Left Ventricular Dysfunction (SOLVD). South Med J. 1995;88: 514–23.

    PubMed  CAS  Google Scholar 

  9. Chin MH, Friedmann PD, Cassel CK, Lang RM. Differences in generalist and specialist physicians' knowledge and use of angiotensin-converting enzyme inhibitors for congestive heart failure. J Gen Intern Med. 1997;12:523–30.

    Article  PubMed  CAS  Google Scholar 

  10. Rajfer SI. Perspective of the pharmaceutical industry on the development of new drugs for heart failure. J Am Coll Cardiol. 1993; 22(suppl A):198–200A.

    Article  Google Scholar 

  11. Chodoff P, Bischof RO, Nash DB, Laine C. The AHCPR guidelines on heart failure: comparison of a family medicine and an internal medicine practice with the guidelines and an educational intervention to modify behavior. Clin Performance Qual Healthcare. 1996; 4:179–85.

    Google Scholar 

  12. Konstam M, Dracup K, Baker D, et al. Heart Failure: Evaluation and Care of Patients with Left-Ventricular Systolic Dysfunction. Clinical Practice Guideline No. 11. Rockville, Md: Agency for Health Care Policy and Research, Public Health Service, U.S. Department of Health and Human Services: June 1994. AHCPR publication no. 94-0612.

    Google Scholar 

  13. American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Guidelines for the evaluation and management of heart failure. J Am Coll Cardiol. 1995;26:1376–98.

    Article  Google Scholar 

  14. U.S. Health Care Financing Administration. The International Classification of Diseases, 9th Revision, Clinical Modification, Washington, DC: U.S. Department of Health and Human Services; 1991.

    Google Scholar 

  15. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987;40:373–83.

    Article  PubMed  CAS  Google Scholar 

  16. Cleland JGF, Hubbard WN, Pittard J, Poole-Wilson PA, Sutton GC. ACE inhibitors in heart failure: what dose? BMJ. 1995;71:65–6.

    CAS  Google Scholar 

  17. O'Connell JB, Cobb AB. Heart failure evaluation and treatment in Mississippi: results from a survey of the Mississippi foundation for medical care. J Miss State Med Assoc. 1996;37:648–51.

    Google Scholar 

  18. Lamas GA, Pfeffer MA, Hamm P, Wertheimer J, Rouleau JL, Braunwald E. Do the results of randomized clinical trials of cardiovascular drugs influence medical practice? N Engl J Med. 1992;327:241–7.

    Article  PubMed  CAS  Google Scholar 

  19. Packer M. Do angiotensin-converting enzyme inhibitors prolong life in patients with heart failure treated in clinical practice? J Am Coll Cardiol. 1996;28:1323–7.

    Article  Google Scholar 

  20. Visser FC, Visser CA. Current controversies with ACE inhibitor treatment in heart failure. Cardiology. 1996;87(suppl 1):23–8.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Funded by a grant-in-aid from the American Heart Association of Metropolitan Chicago and a University of Chicago Home Health Care Grant. Dr. Chin is supported by National Institutes of Health/National Institute on Aging Geriatric Academic Program Award 5-K12-AG-00488.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chin, M.H., Wang, J.C., Žhang, J.X. et al. Utilization and dosing of angiotensin-converting enzyme inhibitors for heart failure. J GEN INTERN MED 12, 563–566 (1997). https://doi.org/10.1046/j.1525-1497.1997.07110.x

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1046/j.1525-1497.1997.07110.x

Key words

Navigation