Abstract
A pilot study using actigraph was conducted to assess the effects of a 1-week repeated administration of 15 mg of quazepam on the sleep and daytime activity of six healthy adults. The nocturnal sleep time gradually increased during quazepam administration, and a significant difference from the baseline was noted on the seventh day of administration. There was no significant difference in the daytime activity before and after the administration. Quazepam and its active metabolites appear to have acted on the level not affecting the daytime activity but prolonging the nocturnal sleep time through their interactions.
This is a preview of subscription content, log in via an institution to check access.
References
Hilbert JM, Battista D. Quazepam and flurazepam: differential pharmacokinetic and pharmacodynamic characteristics. J. Clin. Psychiatry 1991; 52: 21–6.
Dement WC. Objective measurements of daytime sleepiness and performance comparing quazepam with flurazepam in two adult populations using the Multiple Sleep Latency Test. J. Clin. Psychiatry 1991; 52: 31–7.
Sadeh A, Hauri PJ, Kripke DF et al. The role of actigraphy in the evaluation of sleep disorders. Sleep 1995; 18: 288–302.
Volicer L, Harper DG, Manning BC et al. Sundowning and circadian rhythms in Alzheimer’s disease. Am. J. Psychiatry 2001; 158: 704–11.
Schaffler K, Kauert G, Wauschkuhn CH et al. Longitudinal study on pharmacodynamics and pharmacokinetics of acute, steady-state and withdrawn quazepam. Arzneimittelforschung 1989; 39: 276–83.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kusunoki, K., Kitajima, T. & Ozaki, N. Does quazepam influence sleep and daytime activity in healthy adults?. Sleep Biol. Rhythms 1, 171–172 (2003). https://doi.org/10.1046/j.1446-9235.2003.00036.x
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1046/j.1446-9235.2003.00036.x