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Literature-based values of control subjects in sleep medicine

Literaturdaten schlafmedizinischer Untersuchungen von Kontrollpatienten

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Summary

Question of the Study

To establish literature-based values of control subjects in sleep medicine. These data should give a range for the interpretation of polysomnographic results.

Patients and methods

We systematically collected and pooled data of control subjects in different sleep studies. We calculated the weighted arithmetical mean of these data, i. e. the mean of the means of multiple studies, with consideration being given to the number of the individual values concerned. Since the data in the literature were not presented uniformly, we were not able to establish standard deviations. Reported sleep stages were accepted only when the Rechtschaffen and Kales classification was applied. Arousals were accepted only if established in accordance with the criteria of the American Academy of Sleep Medicine. Whenever possible we calculated data broken down for age groups.

Results

Usable data were obtained from studies of between 10 and 1023 control subjects. The age range extended from infancy to 85 years. Data on sleep stages, sleep latencies, arousals, oxygen saturation, partial pressure of carbon dioxide, apneas and hypopneas were processed. Sleep latency and proportion of sleep stages are influenced by the first-night effect.

Conclusions

The data reflect the current status. When more control data are published the tables will have to be updated.

Zusammenfassung

Fragestellung

Zur Beurteilung von polysomnographischen Messergebnissen sind Vergleichswerte von Untersuchungen von Kontrollpersonen erforderlich.

Patienten und Methodik

Schlafmedizinische Daten gesunder Kontrollpersonen, meist als Kontrollkollektiv verschiedenster Studien aufgeführt, wurden systematisch zusammengestellt. Anhand der Zahl der Untersuchten wurde das gewogene arithmetische Mittel berechnet (Mittelwert aus Mittelwerten einzelner Studien unter Berücksichtigung der Anzahl der zugrunde liegenden Einzelwerte). Da die Daten in unterschiedlichen Studien nicht einheitlich präsentiert werden, konnten für alle Messwerte zwar Mittelwerte, aber nicht Standardabweichungen oder Bereiche (Range) angegeben werden. Schlafstadien wurden dann übernommen, wenn die Einteilung nach Rechtschaffen und Kales erfolgte. Arousals sind nur aufgeführt bei Bestimmung gemäß den Kriterien der American Academy of Sleep Medicine. Sofern aus den Studien ersichtlich wurden die Referenzwerte in Altersklassen dekadenweise eingeteilt.

Ergebnisse

Die einzelnen Studien umfassen Werte von 10 bis 1023 Probanden. Der Bereich beginnt bei Säuglingen und endet bei 85 Jahren. Es werden Ergebnisse zu Schlafstadien, Schlaflatenzen, Arousals, Sauerstoffsättigung, Kohlendioxidpartialdruck und Apnoen sowie Hypopnoen präsentiert. Die Schlaflatenz sowie die Verteilung der Schlafstadien können erst nach einer Adaptionsnacht zuverlässig beurteilt werden.

Schlussfolgerungen

Die Daten fassen den augenblicklichen Stand zusammen. Bei Veröffentlichung neuerer umfangreicher Messergebnisse müssen die Tabellen aktualisiert werden.

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Authors and Affiliations

  1. Krank enhaus Großhansdorf, Zentrum für Pneumologie und Thorax chirurgie, Wöhrendamm 80, 22927, Großhansdorf, Germany

    Holger Hein & Helgo Magnussen

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  1. Holger Hein
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Correspondence to Holger Hein.

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Hein, H., Magnussen, H. Literature-based values of control subjects in sleep medicine. Somnologie 7, 28–34 (2003). https://doi.org/10.1046/j.1439-054X.2003.02194.x

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