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Photodynamic treatment of melanoma cells using aza-dipyrromethenes as photosensitizers

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Abstract

In this study, we report for the first time the use of four aza-dipyrromethenes (ADPMs) as photosensitizers for cancer PDT. The synthesis and characterization of the ADPMs and their photodynamic action against B16F10 melanoma cells were assessed. ADPM 2 is the best singlet oxygen generator and the most photo-toxic (at 2.5 μM) towards B16F10 cells.

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Authors and Affiliations

  1. Department of Physics and Chemistry, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, SP, Brazil

    Kelly A. D. F. Castro, Juliana C. Biazzotto & Roberto S. da Silva

  2. LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Portugal

    Letícia D. Costa, Samuel Guieu, Maria Graça P. M. S. da Neves, M. Amparo F. Faustino & Augusto C. Tomé

  3. CICECO – Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, Portugal

    Samuel Guieu

Authors
  1. Kelly A. D. F. Castro
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  2. Letícia D. Costa
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  3. Samuel Guieu
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  5. Maria Graça P. M. S. da Neves
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Correspondence to Kelly A. D. F. Castro.

Additional information

Electronic supplementary information (ESI) available. See DOI: 10.1039/d0pp00114g

These two authors contributed equally to this work.

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Castro, K.A.D.F., Costa, L.D., Guieu, S. et al. Photodynamic treatment of melanoma cells using aza-dipyrromethenes as photosensitizers. Photochem Photobiol Sci 19, 885–891 (2020). https://doi.org/10.1039/d0pp00114g

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