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Poly(butyl cyanoacrylate) nanoparticle containing an organic photoCORM

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Abstract

Carbon monoxide (CO) is a gasotransmitter, which has shown therapeutic effects in recent studies. Photo carbon monoxide releasing molecules (PhotoCORMs) allow the delivery of CO to be controlled by light. In this work, a new organic photoCORM DK4 is studied. DK4 is a diketone type photoCORM, which releases two CO molecules under visible light and simultaneously generates a fluorescent anthracene derivative. However, this type of CORM suffers from a deactivating hydration reaction and often needs to be incorporated in polymers or micelles. The two highly hydrophobic tert-butyl groups of DK4 protect it from the hydration reaction. DK4 functions in 1% DMSO aqueous solution, in which other DKs are deactivated. DK4 was incorporated in a poly(butyl cyanoacrylate) (PBCA) nanoparticle. PBCA has been used as a tissue adhesive and has been extensively studied for delivery of drugs to the brain. The PBCA/DK4 nanoparticle showed good photoactivity and low cytotoxicity, and thus is a promising material for studying the biomedical effects of CO

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Authors and Affiliations

  1. Florida Institute of Technology, Melbourne, Florida, USA

    Adnan Elgattar, Kenyatta S. Washington, Somayeh Talebzadeh, Almutasim Alwagdani, Thaaer Khalil, Osamah Alghazwat, Sultan Alshammri, Hemant Pal, Chris Bashur & Yi Liao

Authors
  1. Adnan Elgattar
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  2. Kenyatta S. Washington
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  3. Somayeh Talebzadeh
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  4. Almutasim Alwagdani
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  5. Thaaer Khalil
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  6. Osamah Alghazwat
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  7. Sultan Alshammri
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  8. Hemant Pal
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  9. Chris Bashur
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  10. Yi Liao
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Corresponding author

Correspondence to Yi Liao.

Additional information

Electronic supplementary information (ESI) available. See DOI: 10.1039/c9pp00287a

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Elgattar, A., Washington, K.S., Talebzadeh, S. et al. Poly(butyl cyanoacrylate) nanoparticle containing an organic photoCORM. Photochem Photobiol Sci 18, 2666–2672 (2019). https://doi.org/10.1039/c9pp00287a

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  • DOI: https://doi.org/10.1039/c9pp00287a

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