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The new supra molecular nano-aggregate curcumin-cucurbit[7]uril: synthesis, photophysical properties and biocompatibility evaluation

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Abstract

The supramolecular nano-aggregate CUR-CB[7] (CUR = curcumin and CB[7] = cucurbit[7]uril) was efficiently prepared by mixing CUR. and CB[7] at a molar ratio of 1:1 in ethanol at room temperature. The supramolecular aggregate formation was evidenced by mainly FTIR, 1H. NMR, DOSY. and spectroscopy experiments. The supramolecular arrangement promotes the increase in the solubility and stability of CUR. without affecting the biological properties of the A549 cells. The luminescence properties of CUR. and CUR-CBI7] show anti-Kasha’s rule fluorescence, and their remarkable NIR. emission enables this material to be used as a luminescent probe and marker for in vivo tracking and structural integrity monitoring of the supramolecular complex.

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Authors and Affiliations

  1. Programa de Pós-Graduação em Ciências de Materials, UFPE, Recife, PE, Brazil

    Leandro Araújo de Azevedo & Severino Alves Junior

  2. Departamento de Química Fundamental, UFPE, Recife, PE, Brazil

    Leonis Lourenço da Luz, Ricardo Oliveira Silva, Severino Alves Junior & Iane Bezerra Vasconcelos Alves

  3. Instituto de Ciências Biológica e da Saúde, Universidade Federal de Alagoas, Maceió, Al, Brazil

    Jamylle Nunes Souza de Ferro & Emiliano Barreto

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  1. Leandro Araújo de Azevedo
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Correspondence to Severino Alves Junior.

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de Azevedo, L.A., da Luz, L.L., de Ferro, J.N.S. et al. The new supra molecular nano-aggregate curcumin-cucurbit[7]uril: synthesis, photophysical properties and biocompatibility evaluation. Photochem Photobiol Sci 16, 663–671 (2017). https://doi.org/10.1039/c6pp00408c

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