Skip to main content
SpringerLink
Log in

A novel phthalazine based highly selective chromogenic and fluorogenic chemosensor for Co2+ in semi-aqueous medium: application in cancer cell imaging

  • Paper
  • Published:
Photochemical & Photobiological Sciences Aims and scope Submit manuscript

Abstract

A new phthalazine based chemosensor 3 was developed for the highly selective and sensitive detection of Co2+ in the mixed solvent system, CH3CN-H2O (1 : 1, v/v). In the presence of Co2+, the colour of the solution 3 changed from yellow to green; the absorption maxima of 3 was red-shifted from 383 nm to 435 nm, and the fluorescence of 3 at 550 nm was significantly enhanced. The sensor 3 showed a detection limit down to 25 nM by forming a complex species with Co2+ in 1 : 1 stoichiometry. Furthermore, by means of confocal laser scanning microscopy experiments, it has demonstrated that it can be used as a fluorescent probe for monitoring Co2+ in living cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. P. de Silva, H. Q. N. Gunaratne, T. Gunnlaugsson, A. J. M. Huxley, C. P. McCoy, J. T. Rademacher, T. E. Rice, Chem. Rev. 1997 97 1515.

    Article  Google Scholar 

  2. S. K. Sahoo, D. Sharma, R. K. Bera, G. Crisponi, J. F. Callan, Chem. Soc. Rev. 2012 41 7195.

    Article  CAS  Google Scholar 

  3. K. J. Wallace, Supramol. Chem. 2009 21 89.

    Article  CAS  Google Scholar 

  4. M. Pan, X. M. Lin, G. B. Li, C. Y. Su, Coord. Chem. Rev. 2011 255 1921.

    Article  CAS  Google Scholar 

  5. U. Fegade, H. Sharma, N. Singh, S. Ingle, S. Attarde, A. Kuwar, J. Lumin. 2014 149 190.

    Article  CAS  Google Scholar 

  6. U. Fegade, A. Singh, G. K. Chaitanya, N. Singh, S. Attarde, A. Kuwar, Spectrochim. Acta, Part A 2014 121 569–574.

    Article  CAS  Google Scholar 

  7. U. Fegade, J. Marek, R. Patil, S. Attarde, A. Kuwar, J. Lumin. 2014 146 234–238.

    Article  CAS  Google Scholar 

  8. U. Fegade, H. Sharma, S. Attarde, N. Singh, A. Kuwar, J. Fluoresc. 2014 24 27–37.

    Article  CAS  Google Scholar 

  9. U. Fegade, S. Attarde, A. Kuwar, Chem. Phys. Lett. 2013 584 165–171.

    Article  CAS  Google Scholar 

  10. U. Fegade, A. Saini, S. K. Sahoo, N. Singh, R. Bendre, A. Kuwar, RSC Adv. 2014 4 39639–39644.

    Article  CAS  Google Scholar 

  11. U. Fegade, S. Tayade, G. K. Chaitanya, S. Attarde, A. Kuwar, J. Fluoresc. 2014 24 675–681.

    Article  CAS  Google Scholar 

  12. K. Huang, H. Yang, Z. Zhou, M. Yu, F. Li, X. Gao, T. Yi, C. Huang, Org. Lett. 2008 10 2557.

    Article  CAS  Google Scholar 

  13. Y. Wu, H. Jing, Z. Dong, Q. Zhao, H. Wu, F. Li, Inorg. Chem. 2011 50 7412.

    Article  CAS  Google Scholar 

  14. H. Lu, L. Xiong, H. Liu, M. Yu, Z. Shen, F. Li, X. You, Org. Biomol. Chem. 2009 7, 12, 2554.

    Article  CAS  Google Scholar 

  15. U. Fegade, H. Sharma, B. Bondhopadhyay, A. Basu, S. Attarde, N. Singh, A. Kuwar, Talanta 2014 125 418.

    Article  CAS  Google Scholar 

  16. O. Karovic, I. Tonazzini, N. Rebola, E. Edström, C. Lövdahl, B. B. Fredholm, E. Dare, Biochem. Pharmacol. 2007 73 694.

    Article  CAS  Google Scholar 

  17. R. Lauwerys, D. Lison, Sci. Total Environ. 1994 150 1.

    Article  CAS  Google Scholar 

  18. R. Suardi, L. Belotti, M. T. Ferrari, P. Leghissa, M. Caironi, L. Maggi, F. Alborghetti, T. Storto, T. Silva, S. Piazzolla, Sci. Total Environ. 1994 150 197.

    Article  CAS  Google Scholar 

  19. K. Redda, L. A. Corleto, E. E. Knaus, J. Med. Chem. 1979 22 1079.

    Article  CAS  Google Scholar 

  20. D. R. Williams, The metal of Life the solution chemistry of metal ions in biological system, Van Nostrand, London, 1971.

    Google Scholar 

  21. M. J. Seven, and L. A. Johnson, Metal Binding in Medicine, Lippincott Co, Philadelphia P.A, 4th edn, 1960.

    Google Scholar 

  22. H. G. Seiler, A. Siegel, and H. Siegel, Handbook on Metals in Clinical Analytical Chemistry, Marcel Dekker, New York, 1994, 333–338.

    Google Scholar 

  23. M. J. Frisch, et al., Gaussian 09, G09W®, Gaussian Inc. Wallingford, USA, 2009.

    Google Scholar 

  24. U. Fegade, S. K. Sahoo, S. Attarde, N. Singh, A. Kuwar, Sens. Actuators, B 2014 202 924.

    Article  CAS  Google Scholar 

  25. R. Patil, A. Moirangthem, R. Butcher, N. Singh, A. Basu, K. Tayade, U. Fegade, D. Hundiwale, A. Kuwar, Dalton Trans. 2014 43 2895.

    Article  CAS  Google Scholar 

  26. A. Basoglu, S. Parlayan, M. Ocak, H. Alp, H. Kantekin, M. Ozdemir, U. Ocak, J. Fluoresc. 2009 19 655.

    Article  CAS  Google Scholar 

  27. H. Y. Luo, X. B. Zhang, C. L. He, G. L. Shen, R. Q. Yu, Spectrochim. Acta, Part A 2008 70 337.

    Article  Google Scholar 

  28. P. Job, Ann. Chim. 1928 9 113.

    CAS  Google Scholar 

  29. H. A. Benesi, J. H. Hildebrand, J. Am. Chem. Soc. 1949 71 2703.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Chemical Sciences, North Maharashtra University, Jalgaon, 425 001, MS, India

    Smita Patil, Rahul Patil, Umesh Fegade, Umesh Pete, Ratnamala Bendre & Anil Kuwar

  2. Molecular Biology and Human Genetics Laboratory, Department of Zoology, The University of Burdwan, Burdwan, West Bengal, India

    Banashree Bondhopadhyay & Anupam Basu

  3. Department of Applied Chemistry, SV National Institute of Technology, Surat, Gujrat, India

    Suban K. Sahoo

  4. Department of Chemistry, Indian Institute of Technology, Ropar, 140 001, Punjab, India

    Narinder Singh

Authors
  1. Smita Patil
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rahul Patil
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Umesh Fegade
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Banashree Bondhopadhyay
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Umesh Pete
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Suban K. Sahoo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Narinder Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Anupam Basu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Ratnamala Bendre
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Anil Kuwar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Anupam Basu, Ratnamala Bendre or Anil Kuwar.

Additional information

Electronic supplementary information (ESI) available. See DOI: 10.1039/c4pp00358f

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Patil, S., Patil, R., Fegade, U. et al. A novel phthalazine based highly selective chromogenic and fluorogenic chemosensor for Co2+ in semi-aqueous medium: application in cancer cell imaging. Photochem Photobiol Sci 14, 439–443 (2015). https://doi.org/10.1039/c4pp00358f

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1039/c4pp00358f

Search

Navigation