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A computational model for previtamin D3 production in skin

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Abstract

Low levels of vitamin D have been implicated in a wide variety of health issues from calcemic diseases to cancer, diabetes and cardiovascular disease. For most humans, the majority of vitamin D3 is derived from sunlight. How much vitamin D is produced under given exposure conditions is still widely discussed. We present a computational model for the production of (pre-)vitamin D within the skin. It accounts for spectral irradiance, optical properties of the skin and concentration profile of provitamin D. Results are computed for various sets of these parameters yielding the distribution of produced previtamin D in the skin.

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Authors and Affiliations

  1. HOT-Hanover Center for Optical Technologies, Leibniz Universität Hannover, Nienburger Str. 17, 30167 Hannover, Germany

    Merve Meinhardt-Wollweber

  2. Krebs–sciResolve–Scientific Research Solutions, Windheimstr. 21, 30451 Hannover, Germany

    Ronald Krebs

Authors
  1. Merve Meinhardt-Wollweber
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  2. Ronald Krebs
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Correspondence to Merve Meinhardt-Wollweber.

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† Vitamin D denotes vitamin D3 unless otherwise indicated

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Meinhardt-Wollweber, M., Krebs, R. A computational model for previtamin D3 production in skin. Photochem Photobiol Sci 11, 731–737 (2012). https://doi.org/10.1039/c2pp05295d

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  • DOI: https://doi.org/10.1039/c2pp05295d

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