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Combination of photodynamic therapy and immunomodulation for skin diseases—update of clinical aspects

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Abstract

In dermatology, photodynamic therapy (PDT) has become a well established treatment modality which has been shown to be effective and safe for many skin and mucosal disorders. Pre-clinical and clinical studies demonstrate that, in addition to the direct local cytotoxicity and vascular effects, PDT can induce various host immune responses. Recent clinical data also show that improved clinical outcomes can be obtained through the sequential use of PDT and immunomodulation. This article will provide an update on the current status of such a combination in dermatological applications.

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Authors and Affiliations

  1. PDT Center, Shanghai Skin Diseases and STD Hospital, Shanghai, P. R. China

    Xiu-Li Wang & Hong-Wei Wang

  2. Laser Plastic and Aesthetic Center, The General Hospital of Guangzhou Military Command, Guangzhou, P. R. China

    Kai-Hua Yuan

  3. Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China

    Fu-Lun Li

  4. School of Medicine, University ofColorado Denver, Denver, Colorado, USA

    Fu-Lun Li & Zheng Huang

  5. National Jewish Health, Denver, Colorado, USA

    Zheng Huang

  6. MOE Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Normal University, Fuzhou, P. R. China

    Zheng Huang

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  1. Xiu-Li Wang
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Correspondence to Zheng Huang.

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This article is published as part of a themed issue on immunological aspects and drug delivery technologies in PDT.

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Wang, XL., Wang, HW., Yuan, KH. et al. Combination of photodynamic therapy and immunomodulation for skin diseases—update of clinical aspects. Photochem Photobiol Sci 10, 704–711 (2011). https://doi.org/10.1039/c0pp00373e

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