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Preliminary safety and efficacy results of laser immunotherapy for the treatment of metastatic breast cancer patients

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Abstract

We report our preliminary results of a pilot clinical trial of late-stage breast cancer patients treated by laser immunotherapy (LIT), a local intervention using an 805 nm laser for non-invasive irradiation, indocyanine green for selective thermal effect, and immunoadjuvant (glycated chitosan) for immunological stimulation. Ten breast cancer patients were enrolled in this study; all patients were considered to be out of other available treatment options. Toxicity was individually evaluated through physical exams and laboratory tests. Adverse reactions only occurred in the area of treatment due to photothermal injury and local administration of immunoadjuvant. No grade 3 or 4 side effects were observed. Treatment efficacy of LIT was also evaluated by physical examination and tomography. In 8 patients available for evaluation, the objective response rate was 62.5% and the clinical beneficial response rate was 75%. While the study is still ongoing, the initial outcomes of this clinical trial show that LIT is well tolerated and is promising in the treatment of metastatic breast cancer.

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Authors and Affiliations

  1. Department of Oncology, The First Affiliated Hospital of Chinese PLA General Hospital, Beijing, 100048, China

    Xiaosong Li

  2. Department of Laser Medicine, Chinese PLA General Hospital, Beijing, 100853, China

    Xiaosong Li

  3. Department of Engineering and Physics, University of Central Oklahoma, 100 N. University Drive, Edmond, Oklahoma, 73034, USA

    Xiaosong Li & Wei R. Chen

  4. Hospital Nacional Edgardo Rebagliati Martins, Av. Edgardo Rebagliati #490-Jesus Maria, Lima, Peru

    Gabriela L. Ferrel

  5. Immuno Photonics Inc., 1601 South Providence Road, Columbia, Missouri, 65211, USA

    Maria C. Guerra, Tomas Hode & Robert E. Nordquist

  6. Commonwealth Medical Research Institute, # 8 Collins Avenue, Nassau, Bahamas

    John A. Lunn

  7. International Strategic Cancer Alliance, 873 E. Baltimore Pike #333, Kennett Square, Philadelphia, 19348, USA

    Orn Adalsteinsson

  8. Center for Bioengineering and School of Electrical and Computer Engineering, University of Oklahoma, 202 West Boyd, Room 219, Norman, Oklahoma, 73019, USA

    Hong Liu

Authors
  1. Xiaosong Li
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  2. Gabriela L. Ferrel
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  3. Maria C. Guerra
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  4. Tomas Hode
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  5. John A. Lunn
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  6. Orn Adalsteinsson
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  7. Robert E. Nordquist
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  8. Hong Liu
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  9. Wei R. Chen
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Corresponding author

Correspondence to Wei R. Chen.

Additional information

This article is published as part of a themed issue on immunological aspects and drug delivery technologies in PDT.

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Li, X., Ferrel, G.L., Guerra, M.C. et al. Preliminary safety and efficacy results of laser immunotherapy for the treatment of metastatic breast cancer patients. Photochem Photobiol Sci 10, 817–821 (2011). https://doi.org/10.1039/c0pp00306a

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  • DOI: https://doi.org/10.1039/c0pp00306a

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