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Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy

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Abstract

For the first time we present data showing that metabolic targeted therapy with dichloroacetate (DCA) may improve the outcome of photodynamic therapy. This treatment modality can be easily introduced into clinical practice guidelines.

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Abbreviations

PpIX:

Protoporphyrin IX

PDT:

Photodynamic therapy

PS:

Photosensitizer

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Authors and Affiliations

  1. Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Montebello, Oslo, 0310, Norway

    Mateusz Kwitniewski, Johan Moan & Asta Juzeniene

  2. Institute of Physics, University of Oslo, Blindern, 0316, Oslo, Norway

    Johan Moan

Authors
  1. Mateusz Kwitniewski
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  2. Johan Moan
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  3. Asta Juzeniene
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Correspondence to Mateusz Kwitniewski.

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Kwitniewski, M., Moan, J. & Juzeniene, A. Metabolic-targeted therapy with dichloroacetate (DCA): a novel treatment strategy to improve the outcome of photodynamic therapy. Photochem Photobiol Sci 10, 25–28 (2011). https://doi.org/10.1039/c0pp00193g

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  • DOI: https://doi.org/10.1039/c0pp00193g

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