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Excited state behaviour of substituted dipyridophenazine Cr(iii) complexes in the presence of nucleic acids

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Abstract

The photophysics and photochemistry of [Cr(phen)2(dppz)]3+ and its 11,12-substituted derivatives [Cr(phen)2(X2dppz)]3+ {X = Me or F } have been studied in the presence of purine nucleotides or DNA using steady state and time-resolved absorption and luminescence spectroscopy. 5′-Adenosine monophosphate (5′-AMP ) shows only a weak interaction with the excited states of each complex. By contrast they are efficiently quenched by 5′-guanosine monophosphate (5′-GMP ), consistent with photo-induced electron transfer. Laser flash photolysis spectroscopy in the presence of 5′-GMP suggests that both forward and back electron-transfers are rapid. All complexes also display a strong affinity for DNA and evidence for both static and dynamic quenching mechanisms is provided.

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  1. Susan J. Quinn

    Present address: School of Chemistry and Chemical Biology and Centre for Chemical Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin 4, Ireland

Authors and Affiliations

  1. School of Chemistry, University of Dublin, Trinity College College Green, Dublin 2, Ireland

    Michal Wojdyla, Jayden A. Smith, Suni Vasudevan, Susan J. Quinn & John M. Kelly

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  1. Michal Wojdyla
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Correspondence to John M. Kelly.

Additional information

The authors would like to pay tribute to the many contributions of Jan Verhoeven to photochemistry and photophysics.

Electronic supplementary information (ESI) available: Tabulated absorption data and emission peak-fitting parameters, emission decays, time-resolved emission spectra, emission-quenching spectra, Stern-Volmer plots of steady state and lifetime quenching, time-resolved absorption spectra and decay plots.

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Wojdyla, M., Smith, J.A., Vasudevan, S. et al. Excited state behaviour of substituted dipyridophenazine Cr(iii) complexes in the presence of nucleic acids. Photochem Photobiol Sci 9, 1196–1202 (2010). https://doi.org/10.1039/c0pp00110d

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