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A new protocol in photodynamic therapy: enhanced tumour cell death by combining two different photosensitizers

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Abstract

The combined application of two photosensitisers (PSs), zinc(ii) phthalocyanine (ZnPc) and the cationic porphyrinmeso-tetrakis(4-N-methylpyridyl)porphine (T4MPyP), on HeLa cells produced an enhanced lethal effect relative to treatments with single PSs. Thus, the proper combination of PSs may constitute a new strategy to improve the efficacy of clinical photodynamic therapy.

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Authors and Affiliations

  1. Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Darwin 2, Edificio de Biología, E-28049, Madrid, Spain

    Angeles Villanueva, Juan Carlos Stockert, Magdalena Cañete & Pilar Acedo

  2. Centro de Investigaciones Biológicas, CSIC, Ramiro de Maeztu 9, E-28040, Madrid, Spain

    Juan Carlos Stockert

Authors
  1. Angeles Villanueva
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  2. Juan Carlos Stockert
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  3. Magdalena Cañete
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  4. Pilar Acedo
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Correspondence to Angeles Villanueva.

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Villanueva, A., Stockert, J.C., Cañete, M. et al. A new protocol in photodynamic therapy: enhanced tumour cell death by combining two different photosensitizers. Photochem Photobiol Sci 9, 295–297 (2010). https://doi.org/10.1039/b9pp00153k

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  • DOI: https://doi.org/10.1039/b9pp00153k

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