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Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity

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Abstract

Irradiation of amelanotic melanoma B78H1 cells in the presence of liposome-delivered Ni(ii)-octabutoxy-naphthalocyanine with a Q-switched Ti:sapphire laser operated in a pulsed mode (850 nm, 30 ns pulses, 10 Hz, 120 mJ pulse−1) promotes a photothermal sensitization process leading to extensive cell inactivation. The photoprocess occurs with identical efficiency in N2-saturated and air-equilibrated media, indicating that this photosensitization modality does not require the presence of oxygen.

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Authors and Affiliations

  1. Department of Biology, University of Padova, Via U. Bassi 58/B, 35131, Padova, Italy

    Monica Camerin & Giulio Jori

  2. Department of Chemistry, Bowling Green State University, Ohio, USA

    Michael A. J. Rodgers

  3. Department of Chemistry, Case Western University, Cleveland, USA

    Malcolm E. Kenney

Authors
  1. Monica Camerin
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  2. Michael A. J. Rodgers
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  3. Malcolm E. Kenney
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  4. Giulio Jori
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Corresponding author

Correspondence to Giulio Jori.

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Camerin, M., Rodgers, M.A.J., Kenney, M.E. et al. Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity. Photochem Photobiol Sci 4, 251–253 (2005). https://doi.org/10.1039/b416418k

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  • DOI: https://doi.org/10.1039/b416418k

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