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Figure 2: Analysis of the performance of the barcoding strategy in five clinical samples. | Scientific Reports

Figure 2: Analysis of the performance of the barcoding strategy in five clinical samples.

From: Asymmetrical barcode adapter-assisted recovery of duplicate reads and error correction strategy to detect rare mutations in circulating tumor DNA

Figure 2: Analysis of the performance of the barcoding strategy in five clinical samples.

The observed allele frequency distributions after error correction for each sample are plotted. The central peaks (amino acid numbers 12 and 13) of chromosome 12 in the graph are the primary mutations detected in the sample. The major-mutation peaks of samples (a) ctDNA1, (b) ctDNA2, (c) ctDNA3, (d) ctDNA4 and (e) ctDNA5 are indicated by the arrows. The allele frequency was calculated within a specific 200-bp region of chromosome 12.

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