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Figure 7 | Scientific Reports

Figure 7

From: Thromboxane A2 receptor antagonist SQ29548 reduces ischemic stroke-induced microglia/macrophages activation and enrichment, and ameliorates brain injury

Figure 7

SQ29548 reduced blood-brain barrier destruction in mice after tMCAO injury.

(A) Immunofluorescence double staining for CD31 with ZO-1 or occludin in the ipsilateral striatum of sham-PBS (n = 4), tMCAO-DMSO (n = 8) and tMCAO-SQ29548 (n = 8) groups at 3 d, 7 d following tMCAO. (B) Analysis of ZO-1 and occludin protein levels at 3 d, 7 d following tMCAO. Quantification of densitometric value of the protein bands normalized to the respective β-tubulin was also shown. Full-length blots/gels are presented in Supplementary Figure S2. The gels have been run under the same experimental conditions. Scale bar = 50 μm. Values are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.

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