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Figure 6 | Scientific Reports

Figure 6

From: Thromboxane A2 receptor antagonist SQ29548 reduces ischemic stroke-induced microglia/macrophages activation and enrichment, and ameliorates brain injury

Figure 6

SQ29548 reduced inflammatory cytokine production and alleviated oxidative stress response in tMCAO mice.

(A) mRNA levels of pro-inflammatory mediators IL-1ß (a), IL-6 (b), TNF-α (c), IL-10 (d) normalized to Rplp0 in the ipsilateral striatum. (B) mRNA levels of antioxidant mediator of SOD2 (a), catalase (b) and oxidative stress factor iNOS (c) normalized to Rplp0 in the ipsilateral striatum of sham-PBS (n = 4), tMCAO-DMSO (n = 8) and tMCAO-SQ29548 (n = 8) groups at 3 d, 7 d following tMCAO. Values are mean ± SEM. *P < 0.05, **P < 0.01.

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