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Figure 5 | Scientific Reports

Figure 5

From: Thromboxane A2 receptor antagonist SQ29548 reduces ischemic stroke-induced microglia/macrophages activation and enrichment, and ameliorates brain injury

Figure 5

SQ29548 reduces M1/M2-type cells after tMCAO injury.

(A,B) Immunofluorescence double staining for Iba-1 (red) with CD16 (green) or Arg-1 (green) in the inner boundary of the infarct striatum of sham-PBS (n = 4), tMCAO-DMSO (n = 8) and tMCAO-SQ29548 (n = 8) groups at 3 d, 7 d following tMCAO. (C) The quantity of microglia/macrophages in the ischemic cerebral striatum is quantified by the intensity of Iba-1+ immunofluorescence. Data were normalized against Iba-1+ level of the sham-PBS group. (D,E) Quantification of the percentage of CD16+/Iba-1+ and Arg-1+/Iba-1+ cells. Scale bar = 50 μm. Values are the mean ± SEM. *P < 0.05, **P < 0.01.

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