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De novo calcification of liver and nodal metastases in prostate carcinoma

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Abstract

Prostate cancer has a distinctly recognized pattern of metastases: multifocal and osteoblastic lesions involving the axial skeleton and non-calcified lymph nodes in the pelvic and lumbar aortic groups. Most adenocarcinomas are capable of producing macrocalcification. We report a case of prostate cancer with de novo calcified metastases to the liver and retroperitoneal lymph nodes mimicking the pattern usually seen in mucin-producing adenocarcinomas arising from the gastrointestinal tract. To our knowledge, this is the first such case to be reported in the literature. We propose a multifactorial mechanism that supports dystrophic calcification in this case. The knowledge of atypical presentation of metastatic disease can prevent diagnostic delay and prompt initiation of therapy.

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Authors and Affiliations

  1. Department of Internal Medicine, University of California, San Diego, San Diego, CA, USA

    P Ghosh

  2. Department of Radiology, University of California, San Diego, San Diego, CA, USA

    A C Santosa

  3. Department of Pathology, University of California, San Diego, San Diego, CA, USA

    G Y Lin

  4. Department of Surgery (Division of Urology), University of California, San Diego, San Diego, CA, USA

    T M Downs

  5. VA San Diego Healthcare System, San Diego, CA, USA

    T M Downs

Authors
  1. P Ghosh
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  2. A C Santosa
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  3. G Y Lin
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  4. T M Downs
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Corresponding author

Correspondence to T M Downs.

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Funding: Departmental.

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Ghosh, P., Santosa, A., Lin, G. et al. De novo calcification of liver and nodal metastases in prostate carcinoma. Prostate Cancer Prostatic Dis 9, 448–451 (2006). https://doi.org/10.1038/sj.pcan.4500875

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  • DOI: https://doi.org/10.1038/sj.pcan.4500875

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