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Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study

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Abstract

This trial investigated the tolerability and effect of modified citrus pectin (Pecta-Sol®) in 13 men with prostate cancer and biochemical prostate-specific antigen (PSA) failure after localized treatment, that is, radical prostatectomy, radiation, or cryosurgery. A total of 13 men were evaluated for tolerability and 10 for efficacy. Changes in the prostate-specific antigen doubling time (PSADT) of the 10 men were the primary end point in the study. We found that the PSADT increased (P-value<0.05) in seven (70%) of 10 men after taking MCP for 12 months compared to before taking MCP. This study suggests that MCP may lengthen the PSADT in men with recurrent prostate cancer.

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References

  1. Eliaz I . The potential role of modified citrus pectin in the prevention of cancer metastasis. Clin Pract Altern Med 2002; 2: 177–179.

    Google Scholar 

  2. Raz A, Lotan R . Endogenous galactoside-binding lectins: a new class of functional tumor cell surface molecules related to metastasis. Cancer Metast Rev 1987; 6: 433–452.

    Article  CAS  Google Scholar 

  3. Bresalier RS et al. Expression of the endogenous galactose-binding protein galectin-3 correlates with the malignant potential of tumors in the central nervous system. Cancer 1997; 80: 776–787.

    Article  CAS  Google Scholar 

  4. Raz A et al. Monoclonal antibodies to endogenous galactose-specific tumor cell lectins. EMBO J 1984; 3: 2979–2983.

    Article  CAS  Google Scholar 

  5. Kidd P . A new approach to metastatic cancer prevention: modified citrus pectin (MCP), a unique pectin that blocks cell surface lectins. Altern Med Rev 1996; 1: 4–10.

    Google Scholar 

  6. Naik H, Kalemkerian G . Inhibition of in vitro tumor cell-endothelial adhesion by modified citrus pectin: a pH modified natural complex carbohydrate [abstr]. Proceedings of the Annual Meeting of the American Association of Cancer Research A377, 1995.

  7. Pienta KJ et al. Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. J Natl Cancer Inst 1995; 87: 348–353.

    Article  CAS  Google Scholar 

  8. Nangia-Makker P, Conklin J, Hogan V, Raz A . Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. J Natl Cancer Inst 2002; 94: 1854–1862.

    Article  CAS  Google Scholar 

  9. Schmid HP, McNeal JE, Stamey TC . Observations on the doubling time of prostate cancer. The use of serial prostate-specific antigen in patients with untreated disease as a measure of increasing cancer volume. Cancer 1993; 71: 2031.

    Article  CAS  Google Scholar 

  10. Stamey TA et al. Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 1987; 317: 909–916.

    Article  CAS  Google Scholar 

  11. Stamey TA, Kabalin JN . Prostate specific antigen in the diagnosis and treatment of adenocarcinoma of the prostate. I. Untreated patients. J Urol 1989; 141: 1070–1075.

    Article  CAS  Google Scholar 

  12. Guess B et al. Using splines to detect changes in PSA doubling times. Prostate 2003; 54: 88–94.

    Article  Google Scholar 

  13. Pound CR et al. Natural history of progression after PSA elevation following radical prostatectomy. JAMA 1999; 281: 1591–1597.

    Article  CAS  Google Scholar 

  14. Roberts SG et al. PSA doubling time as a predictor of clinical progression after biochemical failure following radical prostatectomy for prostate cancer. Mayo Clin Proc 2001; 76: 576–581.

    Article  CAS  Google Scholar 

  15. Sartor CI et al. Rate of PSA rise predicts metastatic versus local recurrence after definitive radiotherapy. Int J Radiat Oncol Biol Phys 1997; 38: 941–947.

    Article  CAS  Google Scholar 

  16. Lee RW, Hanks GE, Hanlan A . Increasing prostate-specific antigen profile following definitive radiation therapy for localized prostate cancer: clinical observations. J Clin Oncol 1997; 15: 230–238.

    Article  CAS  Google Scholar 

  17. Pollack A, Zagars GK, Kavadi VS . Prostate specific antigen doubling time and disease relapse after radiotherapy for prostate cancer. Cancer 1994; 74: 670–678.

    Article  CAS  Google Scholar 

  18. McLaren DB, McKenzie M, Duncan G, Pickles T . Watchful waiting or watchful progression? Prostate specific antigen doubling times and clinical behavior in patients with early-untreated prostate carcinoma. Cancer 1998; 82: 342–348.

    Article  CAS  Google Scholar 

  19. Gross C, Stamey TS, Hancock S, Feldman D . Treatment of early recurrent prostate cancer with 1,25 dihydroxyvitamin D3 (calcitriol). J Urol 1998; 159: 2035–2039.

    Article  CAS  Google Scholar 

  20. Beer TM, Lemmon D, Lowe BA, Henner DW . High-dose weekly oral calcitriol in patients with a rising psa after prostatectomy or radiation for prostate carcinoma. Cancer. 2003; 97: 1217–1224.

    Article  CAS  Google Scholar 

  21. Beer TM et al. Weekly high-dose calcitriol and docetaxel in metastatic androgen-independent prostate cancer. J Clin Oncol 2003; 21: 123–128.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Prostate Oncology Specialist, Marina del Rey, California, USA

    B W Guess, M C Scholz, R Y Lam & H J Johnson

  2. Medical Oncologist, Ashland, Oregon, USA

    S B Strum

  3. Department of Statistics, University of California at Los Angeles, Los Angeles, California, USA

    R I Jennrich

Authors
  1. B W Guess
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  2. M C Scholz
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  3. S B Strum
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  4. R Y Lam
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  5. H J Johnson
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  6. R I Jennrich
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Correspondence to B W Guess.

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Guess, B., Scholz, M., Strum, S. et al. Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study. Prostate Cancer Prostatic Dis 6, 301–304 (2003). https://doi.org/10.1038/sj.pcan.4500679

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  • DOI: https://doi.org/10.1038/sj.pcan.4500679

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