References
Ahnesorg P, Smith P, Jackson SP . (2006). XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell 124: 301–313.
Bassing CH, Alt FW . (2004). The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) 3: 781–796.
Buck D, Moshous D, de Chasseval R, Ma Y, le Deist F, Cavazzana-Calvo M et al. (2006). Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. Eur J Immunol 36: 224–235.
Deckbar D, Birraux J, Krempler A, Tchouandong L, Beucher A, Walker S et al. (2007). Chromosome breakage after G2 checkpoint release. J Cell Biol 176: 748–755.
Karanjawala ZE, Grawunder U, Hsieh CL, Lieber MR . (1999). The nonhomologous DNA end-joining pathway is important for chromosome stability in primary fibroblasts. Curr Biol 9: 1501–1504.
Löbrich M, Rief N, Kuhne M, Heckmann M, Fleckenstein J, Rube C et al. (2005). In vivo formation and repair of DNA double-strand breaks after computed tomography examinations. Proc Natl Acad Sci USA 102: 8984–8989.
Moshous D, Callebaut I, de Chasseval R, Corneo B, Cavazzana-Calvo M, Le Deist F et al. (2001). Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. Cell 105: 177–186.
O'Driscoll M, Cerosaletti KM, Girard P-M, Dai Y, Stumm M, Kysela B et al. (2001). DNA ligase IV mutations identified in patients exhibiting development delay and immunodeficiency. Mol Cell 8: 1175–1185.
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM . (2000). A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10: 886–895.
Riballo E, Kuhne M, Rief N, Doherty A, Smith GC, Recio MJ et al. (2004). A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell 16: 715–724.
Taccioli GE, Rathbun G, Oltz E, Stamato T, Jeggo PA, Alt FW . (1993). Impairment of V(D)J recombination in double-strand break repair mutants. Science 260: 207–210.
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y . (2003). Requirement of the MRN complex for ATM activation by DNA damage. EMBO J 22: 5612–5621.
Wyman C, Kanaar R . (2006). DNA double-strand break repair: all's well that ends well. Annu Rev Genet 40: 363–383.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Jeggo, P., Löbrich, M. DNA double-strand breaks: their cellular and clinical impact?. Oncogene 26, 7717–7719 (2007). https://doi.org/10.1038/sj.onc.1210868
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.onc.1210868
- Springer Nature Limited
This article is cited by
-
Cancer status in the Occupied Palestinian Territories: types; incidence; mortality; sex, age, and geography distribution; and possible causes
Journal of Cancer Research and Clinical Oncology (2023)
-
Identification of a novel mechanism for reversal of doxorubicin-induced chemotherapy resistance by TXNIP in triple-negative breast cancer via promoting reactive oxygen-mediated DNA damage
Cell Death & Disease (2022)
-
Impact of DNA double-strand breaks on pancreaticobiliary maljunction carcinogenesis
Diagnostic Pathology (2021)
-
spn-A/rad51 mutant exhibits enhanced genomic damage, cell death and low temperature sensitivity in somatic tissues
Chromosoma (2021)
-
Quantification of wild-type and radiation attenuated Plasmodium falciparum sporozoite motility in human skin
Scientific Reports (2019)