Skip to main content
SpringerLink
Log in

Regulation of cellular senescence by Rb2/p130

  • Review
  • Published:
Oncogene Submit manuscript

Abstract

Growth regulatory functions of Rb2/p130, which aim at a sustained arrest such as in quiescent or differentiated cells, qualify the protein also to act as a central regulator of growth arrest in cellular senescence. In this respect, Rb2/p130 functions are connected to signaling pathways induced by p53, which is a master regulator in cellular senescence. Here, we summarize the pathways, which specify pRb2/p130 to control this arrest program and distinguish its functions from those of pRb/p105.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2

Similar content being viewed by others

References

  • Alexander K, Hinds PW . (2001). Mol Cell Biol 21: 3616–3631.

  • Araki K, Nakajima Y, Eto K, Ikeda MA . (2003). Oncogene 22: 7632–7641.

  • Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A . (1996). Proc Natl Acad Sci USA 93: 4629–4632.

  • Baldi A, De Luca A, Claudio PP, Baldi F, Giordano GG, Tommasino M et al. (1995). J Cell Biochem 59: 402–408.

  • Baldi A, Esposito V, De Luca A, Fu Y, Meoli I, Giordano GG et al. (1997). Clin Cancer Res 3: 1691–1697.

  • Bates S, Ryan KM, Phillips AC, Vousden KH . (1998). Oncogene 17: 1691–1703.

  • Beausejour CM, Krtolica A, Galimi F, Narita M, Lowe SW, Yaswen P et al. (2003). EMBO J 22: 4212–4222.

  • Braig M, Lee S, Loddenkemper C, Rudolph C, Peters AH, Schlegelberger B et al. (2005). Nature 436: 660–665.

  • Bremner R, Cohen BL, Sopta M, Hamel PA, Ingles CJ, Gallie BL et al. (1995). Mol Cell Biol 15: 3256–3265.

  • Bruce JL, Hurford Jr RK, Classon M, Koh J, Dyson N . (2000). Mol Cell 6: 737–742.

  • Buchkovich K, Duffy LA, Harlow E . (1989). Cell 58: 1097–1105.

  • Campisi J . (2001). Exp Gerontol 36: 607–618.

  • Canhoto AJ, Chestukhin A, Litovchick L, DeCaprio JA . (2000). Oncogene 19: 5116–5122.

  • Chang BD, Swift ME, Shen M, Fang J, Broude EV, Roninson IB . (2002). Proc Natl Acad Sci USA 99: 389–394.

  • Chang BD, Xuan Y, Broude EV, Zhu H, Schott B, Fang J et al. (1999). Oncogene 18: 4808–4818.

  • Chen PL, Scully P, Shew JY, Wang JY, Lee WH . (1989). Cell 58: 1193–1198.

  • Chen Z, Trotman LC, Shaffer D, Lin HK, Dotan ZA, Niki M et al. (2005). Nature 436: 725–730.

  • Classon M, Salama S, Gorka C, Mulloy R, Braun P, Harlow E . (2000). Proc Natl Acad Sci USA 97: 10820–10825.

  • Claudio PP, De Luca A, Howard CM, Baldi A, Firpo EJ, Koff A et al. (1996). Cancer Res 56: 2003–2008.

  • Claudio PP, Howard CM, Baldi A, De Luca A, Fu Y, Condorelli G et al. (1994). Cancer Res 54: 5556–5560.

  • Cobrinik D . (2005). Oncogene 24: 2796–2809.

  • Coisy M, Roure V, Ribot M, Philips A, Muchardt C, Blanchard JM et al. (2004). Mol Cell 15: 43–56.

  • D'Andrilli G, Masciullo V, Bagella L, Tonini T, Minimo C, Zannoni GF et al. (2004). Clin Cancer Res 10: 3098–3103.

  • Dimri GP, Itahana K, Acosta M, Campisi J . (2000). Mol Cell Biol 20: 273–285.

  • Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C et al. (1995). Proc Natl Acad Sci USA 92: 9363–9367.

  • Dong F, Cress Jr WD, Agrawal D, Pledger WJ . (1998). J Biol Chem 273: 6190–6195.

  • Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA . (1993). Cell 73: 499–511.

  • Dunaief JL, Strober BE, Guha S, Khavari PA, Alin K, Luban J et al. (1994). Cell 79: 119–130.

  • Durfee T, Becherer K, Chen PL, Yeh SH, Yang Y, Kilburn AE et al. (1993). Genes Dev 7: 555–569.

  • el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM et al. (1993). Cell 75: 817–825.

  • Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D . (1998). Proc Natl Acad Sci USA 95: 10493–10498.

  • Ghosh MK, Harter ML . (2003). Mol Cell 12: 255–260.

  • Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC . (1999). Cell 98: 859–869.

  • Haupt Y, Rowan S, Oren M . (1995). Oncogene 10: 1563–1571.

  • Hayflick L . (1965). Exp Cell Res 37: 614–636.

  • Hengst L, Reed SI . (1996). Science 271: 1861–1864.

  • Herrera RE, Sah VP, Williams BO, Makela TP, Weinberg RA, Jacks T . (1996). Mol Cell Biol 16: 2402–2407.

  • Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA . (1992). Cell 70: 993–1006.

  • Hong FD, Huang HJ, To H, Young LJ, Oro A, Bookstein R et al. (1989). Proc Natl Acad Sci USA 86: 5502–5506.

  • Howard CM, Claudio PP, De Luca A, Stiegler P, Jori FP, Safdar NM et al. (2000). Cancer Res 60: 2737–2744.

  • Hsiao KM, McMahon SL, Farnham PJ . (1994). Genes Dev 8: 1526–1537.

  • Hurford Jr RK, Cobrinik D, Lee MH, Dyson N . (1997). Genes Dev 11: 1447–1463.

  • Iavarone A, Massague J . (1999). Mol Cell Biol 19: 916–922.

  • Ichimura K, Hanafusa H, Takimoto H, Ohgama Y, Akagi T, Shimizu K . (2000). Gene 251: 37–43.

  • Johnson DG, Ohtani K, Nevins JR . (1994). Genes Dev 8: 1514–1525.

  • Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA et al. (1997). Cell 91: 649–659.

  • Kapic A, Helmbold H, Reimer R, Klotzsche O, Deppert W, Bohn W . (2006). Cell Death Differ 13: 324–334.

  • Kiess M, Gill RM, Hamel PA . (1995). Cell Growth Differ 6: 1287–1298.

  • Krimpenfort P, Quon KC, Mooi WJ, Loonstra A, Berns A . (2001). Nature 413: 83–86.

  • Lacy S, Whyte P . (1997). Oncogene 14: 2395–2406.

  • Lee EY, Cam H, Ziebold U, Rayman JB, Lees JA, Dynlacht BD . (2002). Cancer Cell 2: 463–472.

  • Lee WH, Bookstein R, Hong F, Young LJ, Shew JY, Lee EY . (1987). Science 235: 1394–1399.

  • Li Q, Sakurai Y, Ryu T, Azuma K, Yoshimura K, Yamanouchi Y et al. (2004). Brain Tumor Pathol 21: 121–125.

  • Liu DX, Nath N, Chellappan SP, Greene LA . (2005). Genes Dev 19: 719–732.

  • Ludlow JW, Glendening CL, Livingston DM, DeCarprio JA . (1993). Mol Cell Biol 13: 367–372.

  • Lundberg AS, Weinberg RA . (1998). Mol Cell Biol 18: 753–761.

  • Macaluso M, Cinti C, Russo G, Russo A, Giordano A . (2003). Oncogene 22: 3511–3517.

  • Mayol X, Garriga J, Grana X . (1995). Oncogene 11: 801–808.

  • Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A . (1993). Oncogene 8: 2561–2566.

  • Mihara K, Cao XR, Yen A, Chandler S, Driscoll B, Murphree AL et al. (1989). Science 246: 1300–1303.

  • Milde-Langosch K, Goemann C, Methner C, Rieck G, Bamberger AM, Loning T . (2001). Br J Cancer 85: 546–551.

  • Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A et al. (1999). Genes Dev 13: 1181–1189.

  • Narita M, Nunez S, Heard E, Narita M, Lin AW, Hearn SA et al. (2003). Cell 113: 703–716.

  • Neuman E, Flemington EK, Sellers WR, Kaelin Jr WG . (1994). Mol Cell Biol 14: 6607–6615.

  • Nguyen H, Gitig DM, Koff A . (1999). Mol Cell Biol 19: 1190–1201.

  • Nicolas E, Roumillac C, Trouche D . (2003). Mol Cell Biol 23: 1614–1622.

  • Osifchin NE, Jiang D, Ohtani-Fujita N, Fujita T, Carroza M, Kim SJ et al. (1994). J Biol Chem 269: 6383–6389.

  • Pardee AB . (1989). Science 246: 603–608.

  • Peeper DS, Dannenberg JH, Douma S, te Riele H, Bernards R . (2001). Nat Cell Biol 3: 198–203.

  • Psyrri A, DeFilippis RA, Edwards AP, Yates KE, Manuelidis L, DiMaio D . (2004). Cancer Res 64: 3079–3086.

  • Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM et al. (2002). Cell 109: 335–346.

  • Shan B, Chang CY, Jones D, Lee WH . (1994). Mol Cell Biol 14: 299–309.

  • Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ et al. (2001). Nature 413: 86–91.

  • Shiio Y, Yamamoto T, Yamaguchi N . (1992). Proc Natl Acad Sci USA 89: 5206–5210.

  • Smith EJ, Leone G, DeGregori J, Jakoi L, Nevins JR . (1996). Mol Cell Biol 16: 6965–6976.

  • Steiner MS, Wang Y, Zhang Y, Zhang X, Lu Y . (2000). Oncogene 19: 1297–1306.

  • Stiegler P, De Luca A, Bagella L, Giordano A . (1998). Cancer Res 58: 5049–5052.

  • Strobeck MW, Knudsen KE, Fribourg AF, DeCristofaro MF, Weissman BE, Imbalzano AN et al. (2000). Proc Natl Acad Sci USA 97: 7748–7753.

  • Strober BE, Dunaief JL, Guha, Goff SP . (1996). Mol Cell Biol 16: 1576–1583.

  • Sugrue MM, Shin DY, Lee SW, Aaronson SA . (1997). Proc Natl Acad Sci USA 94: 9648–9653.

  • Susini T, Massi D, Paglierani M, Masciullo V, Scambia G, Giordano A et al. (2001). Hum Pathol 32: 360–367.

  • Takahashi Y, Rayman JB, Dynlacht BD . (2000). Genes Dev 14: 804–816.

  • Taubert S, Gorrini C, Frank SR, Parisi T, Fuchs M, Chan HM et al. (2004). Mol Cell Biol 24: 4546–4556.

  • Tedesco D, Lukas J, Reed SI . (2002). Genes Dev 16: 2946–2957.

  • Timmermann S, Hinds PW, Munger K . (1998). Oncogene 17: 3445–3453.

  • Vairo G, Livingston DM, Ginsberg D . (1995). Genes Dev 9: 869–881.

  • Vaziri H, West MD, Allsopp RC, Davison TS, Wu YS, Arrowsmith CH et al. (1997). EMBO J 16: 6018–6033.

  • Waldman T, Kinzler KW, Vogelstein B . (1995). Cancer Res 55: 5187–5190.

  • Wang Y, Blandino G, Oren M, Givol D . (1998). Oncogene 17: 1923–1930.

  • Yeung RS, Bell DW, Testa JR, Mayol X, Baldi A, Grana X et al. (1993). Oncogene 8: 3465–3468.

  • Zhang HS, Gavin M, Dahiya A, Postigo AA, Ma D, Luo RX et al. (2000). Cell 101: 79–89.

  • Zhu L, van den Heuvel S, Helin K, Fattaey A, Ewen M, Livingston D et al. (1993). Genes Dev 7: 1111–1125.

Download references

Acknowledgements

This work was supported by a grant from Deutsche Krebshilfe (Grant 10-1975). The Heinrich-Pette-Institute is financially supported by Freie und Hansestadt Hamburg and Bundesministerium für Gesundheit.

Author information

Authors and Affiliations

  1. Heinrich-Pette-Institute for Experimental Virology and Immunology at the University of Hamburg, Martinistr, Hamburg, Germany

    H Helmbold, W Deppert & W Bohn

Authors
  1. H Helmbold
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W Deppert
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W Bohn
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to W Bohn.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Helmbold, H., Deppert, W. & Bohn, W. Regulation of cellular senescence by Rb2/p130. Oncogene 25, 5257–5262 (2006). https://doi.org/10.1038/sj.onc.1209613

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1209613

  • Springer Nature Limited

Keywords

This article is cited by

Search

Navigation