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Mysterious liaisons: the relationship between c-Myc and the cell cycle

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Abstract

A large body of physiological evidence shows that either upregulation or downregulation of intracellular c-Myc activity has profound consequences on cell cycle progression. Recent work suggests that c-Myc may stimulate the activity of cyclin E/cyclin-dependent kinase 2 (Cdk2) complexes and antagonize the action of the Cdk inhibitor p27KIP1. Cyclin D/Cdk4/6 complexes have also been implicated as targets of c-Myc activity. However, in spite of considerable effort, the mechanisms by which c-Myc interacts with the intrinsic cyclin/Cdk cell cycle machinery remain undefined.

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References

  • Alevizopoulos K, Vlach J, Hennecke S and Amati B. . 1997 EMBO J. 16: 5322–5333.

  • Amati B, Dalton S, Brooks MW, Littlewood TD, Evan GI and Land H. . 1992 Nature 359: 423–426.

  • Amati B, Brooks MW, Levy N, Littlewood TD, Evans GI and Land H. . 1993a Cell 72: 233–245.

  • Amati B, Littlewood TD, Evan GI and Land H. . 1993b EMBO J. 12: 5083–5087.

  • Amati B, Alevizopoulos K and Vlach J. . 1998 Front. Bioscience 3: 250–268.

  • Baldin V, Likas J, Marcote MJ, Pagano M, Bartek J and Draetta G. . 1993 Genes Dev. 7: 812–821.

  • Bates S, Bonetta L, Macallan D, Parry D, Holder A, Dickson C and Peters G. . 1994 Oncogene 9: 71–79.

  • Beijersbergen RL, Carlee L, Kerkhoven RM and Bernards R. . 1995 Genes Dev. 9: 1340–1353.

  • Beijersbergen RL and Bernards R. . 1996 Biochem. Biophys. Acta 1287: 103–120.

  • Berns K, Hijmans EM and Bernards R. . 1997 Oncogene 15: 1347–1356.

  • Blackwell TK, Kretzner L, Blackwood EM, Eisenman RN and Weintraub H. . 1990 Science 250: 1149–1151.

  • Blackwood EM and Eisenman RN. . 1991 Science 251: 1211–1217.

  • Botz JK, Zerfass-Thome K, Spitkovsky D, Delius H, Votg B, Eilers M, Hatzigeorgiou A and Jansen-Durr P. . 1996 Mol. Cell. Biol. 16: 3401–3409.

  • Bush A, Mateyak M, Dugan K, Obaya A, Adachi S, Sedivy J and Cole M. . 1998 Genes Dev. 12: 3797–3802.

  • Chan FKM, Zhang J, Chen L, Shapiro N and Winotto A. . 1995 Mol. Cell. Biol. 15: 2682–2688.

  • Chellappan SP, Hiebert S, Mudryj M, Horwitz JM and Nevins JR. . 1991 Cell 65: 1053–1061.

  • Cheng M, Sexl V, Sherr CJ and Roussel MF. . 1998 Proc. Natl. Acad. Aci. USA 95: 1091–1096.

  • Cole MD. . 1986 Annu. Rev. Genet. 20: 361–384.

  • Daksis JI, Lu RY, Facchini LM, Marhin WW and Penn LJ. . 1994 Oncogene 9: 3635–3645.

  • Danielian PS, White R, Hoare SA, Fawell SE and Parker MG. . 1993 Mol. Endocrinol. 7: 232–240.

  • Dean M, Levine RA, Ran W, Kindy MS, Sonenshein GE and Campisi J. . 1986 J. Biol. Chem. 261: 9161–9166.

  • Dou GP, Zhao S, Levins AH, Wang J, Helin K and Pardee AB. . 1994 J. Biol. Chem. 169: 1306–1313.

  • Dulic V, Lees E and Reed SI. . 1992 Science 257: 1958–1961.

  • Dynlacht BD, Flores O, Lees JA and Harlow E. . 1994 Genes Dev. 8: 1772–1787.

  • Eilers M, Picard D, Yamamoto K and Bishop JM. . 1989 Nature 340: 66–68.

  • Eilers M, Schirm S and Bishop JM. . 1991 EMBO J. 10: 133–141.

  • Galaktionov K, Chen X and Beach D. . 1996 Nature 382: 511–517.

  • Geng Y, Eaton EN, Picon M, Roberts JM, Lundberg AS, Gifford A, Sardet C and Weinberg RA. . 1996 Oncogene 12: 1173–1180.

  • Gu Y, Rosenblatt J and Morgan DO. . 1992 EMBO J. 11: 3995–4005.

  • Guan K, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG and Xiong Y. . 1994 Genes Dev. 8: 2939–2952.

  • Haas K, Johannes C, Geisen C, Schmidt T, Karsunky H, Blass-Kampmann S, Obe G and Moroy T. . 1997a Oncogene 15: 2615–2623.

  • Haas K, Staller P, Geisen C, Bartek J, Eilers M and Moroy T. . 1997b Oncogene 15: 179–192.

  • Hannon GJ and Beach D. . 1994 Nature 371: 257–261.

  • Harper JW, Adami GR, Wei N, Keyomarsi K and Elledge SJ. . 1993 Cell 75: 805–816.

  • Hatakeyama M, Brill JA, Fink GR and Weinberg RA. . 1994 Genes Dev. 8: 1759–1771.

  • Heikkila R, Schwab G, Wickstrom E, Loke SL, Pluznik DH, Watt R and Neckers LM. . 1987 Nature 328: 445–449.

  • Hengs L and Reed SI. . 1994 Science 271: 1861–1864.

  • Henriksson M and Luscher B. . 1996 Adv. Cancer Res. 68: 109–182.

  • Hiebert SW, Chellapan SP, Horowitz JM and Nevins JR. . 1992 Genes Dev. 6: 177–185.

  • Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI and Weinberg RA. . 1992 Cell 70: 993–1006.

  • Hirai H, Roussel MF, Kato J, Ashmun RA and Sherr CJ. . 1995 Mol. Cell. Biol. 15: 2672–2681.

  • Hoffmann I, Clarke PR, Marcote MJ, Karsenti E and Draetta G. . 1993 EMBO J. 12: 53–63.

  • Hoffmann I, Draetta G and Karsenti E. . 1994 EMBO J. 13: 4302–4310.

  • Holt JT, Redner RL and Nienhuis AW. . 1988 Mol. Cell. Biol. 8: 963–973.

  • Honda R, Ohba Y, Nagata A, Okayama H and Yasuda H. . 1993 FEBS Lett. 318: 331–334.

  • Inghirami G, Grignani F, Sternas L, Lombardi L, Knowles DM and Dalla-Favera R. . 1990 Science 250: 682–686.

  • Jansen-Durr P, Meichle A, Steiner P, Pagano M, Finke K, Botz J, Wessbecher J, Draetta G and Eilers M. . 1993 Proc. Natl. Acad. Sci. USA 90: 3685–3689.

  • Jiang H, Chou HS and Zhu L. . 1998 Mol.Cell. Biol. 18: 5284–5290.

  • Jinno S, Suto K, Nagata A, Igarashi M, Kanaoka Y, Nojima H and Okayama H. . 1994 EMBO J. 13: 1549–1556.

  • Jones RM, Branda J, Johnston KA, Polymenis M, Gadd M, Rustgi A, Callanan L and Schmidt EV. . 1996 Mol. Cell. Biol. 16: 4754–4764.

  • Kaczmarek L, Hyland JK, Watt R, Rosenberg M and Baserga R. . 1985 Science 228: 1313–1315.

  • Karn J, Watson JV, Lowe AD, Green SM and Vedeckis W. . 1989 Oncogene 4: 773–787.

  • Kato GJ, Lee WMF, Chen L and Dang CV. . 1992 Genes Dev. 6: 81–92.

  • Kato J, Matsushime H, Hiebert SW, Ewen M and Sherr CJ. . 1993 Genes Dev. 7: 331–342.

  • Kato J-Y, Matsuoka M, Strom DK and Sherr CJ. . 1994 Mol. Cell. Biol. 14: 2713–2721.

  • Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR and Roberts JM. . 1992 Science 257: 1689–1694.

  • Kretzner L, Blackwood E and Eisenman EN. . 1992 Nature 359: 426–429.

  • Lee MH, Reynisdóttir I and Massagué, J. . 1995 Genes Dev. 9: 639–649.

  • Lee TC, Li L, Philippson L and Ziff EB. . 1997 Proc. Natl. Acad. Sci. USA 94: 12886–12891.

  • Littlewood TD, Hancock DC, Danielian PS, Parker MG and Even GI. . 1995 Nucleic Acids Res. 23: 1686–1690.

  • Lukas J, Herzinger T, Hansen K, Moroni MC, Resnitzky D, Helin K, Reed SI and Bartek J. . 1997 Genes Dev. 11: 1479–1492.

  • Lundberg AS and Weinberg R. . 1998 Mol. Cell. Biol. 18: 753–761.

  • Marhin WW, Chen S, Farcchini LM, Fornace AJJ and Penn LZ. . 1997 Oncogene 14: 2825–2834.

  • Mateyak MK, Obaya AJ, Adachi S and Sedivy JM. . 1997 Cell Growth Diff. 8: 1039–1048.

  • Matsushime H, Roussel MF, Ashmun RA and Sherr CJ. . 1991 Cell 65: 701–713.

  • Matsushime H, Ewen ME, Strom DK, Kato J, Hanks SK, Roussel MF and Sherr CJ. . 1992 Cell 71: 323–334.

  • Meyerson M and Harlow E. . 1994 Mol. Cell. Biol. 14: 2077–2086.

  • Morgan DO. . 1995 Nature 374: 131–134.

  • Morgan DO. . 1997 Annu. Rev. Cell Dev. Biol. 13: 261–291.

  • Müller D, Bouchard C, Rudolph B, Steiner P, Stuckmann I, Saffrich R, Ansorge W, Huttner W and Eilers M. . 1997 Oncogene 15: 2561–2576.

  • Murre C, McCaw PS and Baltimore D. . 1989 Cell 56: 777–783.

  • Ohtani K, DeGregori J and Nevins JR. . 1995 Proc. Natl. Acad. Sci. USA 92: 12146–12150.

  • Oswald F, Lovec H, Moroy T and Lipp M. . 1994 Oncogene 9: 2029–2036.

  • Packham G and Cleveland JL. . 1995 Biochim. Biophys. Acta 1242: 11–28.

  • Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Sal GD, Chau V, Yew PR, Draetta GF and Rolfe M. . 1995 Science 269: 682–685.

  • Pearson BE, Nasheuer HP and Wang TF. . 1991 Mol. Cell. Biol. 11: 2081–2095.

  • Penn LJZ, Brooks MW, Laufer EM and Land H. . 1990 EMBO J. 9: 1113–1121.

  • Pérez-Roger I, Solomon DL, Sewing A and Land H. . 1997 Oncogene 14: 2373–2381.

  • Persson H, Gray HE and Godeau F. . 1985 Mol. Cell. Biol. 5: 2903–2912.

  • Peukert K, Staller P, Schneider A, Carmichael G, Hanel F and Eilers M. . 1997 EMBO J. 16: 5672–5686.

  • Philipp A, Schneider A, Vasrik I, Finke K, Xiong Y, Beach D, Alitalo K and Eilers M. . 1994 Mol. Cell. Biol. 14: 4032–4043.

  • Polyak K, Kato J, Solomon MJ, Sherr CJ, Massagué J, Roberts JM and Koff A. . 1994a Genes Dev. 8: 9–22.

  • Polyak K, Lee M, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P and Massagué J. . 1994b Cell 78: 59–66.

  • Prendergast GC and Ziff EB. . 1989 Nature 341: 392.

  • Prendergast GC and Ziff EB. . 1991 Science 251: 186–189.

  • Prendergast GC, Lawe D and Ziff EB. . 1991 Cell 65: 395–407.

  • Pusch O, Bernaschek G, Eilers M and Hengsschlager M. . 1997 Oncogene 15: 649–656.

  • Quelle DE, Ashmun RA, Shurtleff SA, Kato J-Y, Bar-Sagi D, Roussel MF and Sherr CJ. . 1993 Genes Dev. 7: 1559–1571.

  • Rabbitts PH, Watson JV, Lamond A, Forster A, Stinson MA, Evan G, Fischer W, Atherton E, Sheppard R and Rabbitts TH. . 1985 EMBO J. 4: 2009–2015.

  • Resnitzy D, Gossen M, Bujard H and Reed SI. . 1994 Mol.Cell Biol. 14: 1669–1679.

  • Reynisdóttir I and Massagué J. . 1997 Genes Dev. 11: 492–503.

  • Rosenwald IB, Lazaris KA, Sonenberg N and Schimidt EV. . 1993a Mol. Cell. Biol. 13: 7358–7363.

  • Rosenwald IB, Rhoads DB, Callanan LD, Isselbacher KJ and Schmidt EV. . 1993b Proc. Natl. Acad. Sci. USA 90: 6175–6178.

  • Rosenwald IB, Kaspar R, Rousseau D, Gehrke L, Leboulch P, Chen JJ, Schmidt EV and Sonenberg N. . 1995 J. Biol. Chem. 270: 21176–21180.

  • Roussel MF, Theodoras AM, Pagano M and Sherr CJ. . 1995 Proc. Natl. Acad. Sci. USA 92: 6837–6841.

  • Rudolph BRS, Zwicker J, Henglein B, Muller R, Ansorge W and Eilers M. . 1996 EMBO J. 15: 3065–3076.

  • Russo AA, Jeffrey PD, Patten AK, Massague J and Pavletich NP. . 1996 Nature 382: 325–331.

  • Schulze A, Zerfass K, Spitkovsky D, Middendorp S, Berges J, Helin K, Jansen-Durr P and Henglein B. . 1995 Proc. Natl. Acad. Sci. USA 92: 11264–11268.

  • Sebastian B, Kakizuka A and Hunter T. . 1993 Proc. Natl. Acad. Sci. USA 90: 3521–3524.

  • Serrano M, Hannon GJ and Beach D. . 1993 Nature 366: 704–707.

  • Seth A, Gupta S and Davis RJ. . 1996 Mol. Cell. Biol. 13: 4125–4136.

  • Sheaff RJ, Groudine M, Gordon M, Roberts JM and Clurman BE. . 1997 Genes Dev. 11: 1464–1478.

  • Sherr CJ. . 1995 Trends Biochem. Sci. 20: 187–190.

  • Sherr CJ and Roberts JM. . 1995 Genes Dev. 9: 1149–1163.

  • Shibuya H, Yoneyama M, Nimomiya-Tsuji J, Matsumoto K and Taneguchi T. . 1992 Cell 70: 57–67.

  • Shim H, Dolde C, Lewis BC, Wu CS, Dang G, Jungmann RA, Dalla-Favera R and Dang CV. . 1997 Proc. Natl. Acad. Sci. USA 94: 6658–6663.

  • Solomon DLC, Philipp A, Land H and Eilers M. . 1995 Oncogene 11: 1893–1897.

  • Spencer CA and Groudine M. . 1991 Adv. Cancer Res. 56: 1–48.

  • Steiner P, Philipp A, Lucas J, Godden-Kent D, Pagano M, Mittnacht S, Bartek J and Eilers M. . 1995 EMBO J. 14: 4814–4826.

  • Tavtigian SV, Zabludoff SD and Wold BJ. . 1994 Mol. Cell. Biol. 5: 375–388.

  • Terada Y, Tatsuka M, Jinno S and Okayama H. . 1995 Nature 376: 358–362.

  • Vlach J, Hennecke S, Alevizopoulos K, Conti D and Amati B. . 1996 EMBO J. 15: 6595–6604.

  • Vlach J, Hennecke S and Amati B. . 1997 EMBO J. 16: 5334–5344.

  • Waters CM, Littlewood TD, Hancock DC, Moore JP and Evan GI. . 1991 Oncogene 6: 797–805.

  • Won KA, Xiong Y, Beach D and Gilman M. . 1992 Proc. Natl. Acad. Sci. USA 89: 9910–9914.

  • Wu KJ, Polack A and Dalla-Favera R. . 1999 Science 283: 676–679.

  • Xiao ZX, Giasberg D, Ewen M and Livinsgton DM. . 1996 Proc. Natl. Acad. Sci. USA 93: 4633–4637.

  • Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R and Beach D. . 1993 Nature 366: 701–704.

  • Yang B-S, Geddes TJ, Pogulis RJ, deCrombrugghe B and Freytag SO. . 1991 Mol. Cell. Biol. 11: 2291–2295.

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  1. Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, Rhode Island, USA

    Alvaro J Obaya, Maria K Mateyak & John M Sedivy

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Obaya, A., Mateyak, M. & Sedivy, J. Mysterious liaisons: the relationship between c-Myc and the cell cycle. Oncogene 18, 2934–2941 (1999). https://doi.org/10.1038/sj.onc.1202749

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