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Transgenic models and subcellular pathology — do they tell us what goes wrong in Huntington's disease?

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Abstract

Studies of a transgenic mouse model of Huntington's disease have led to the identification of protein deposits in neuronal nuclei in CAG repeat expansion diseases. The relationship between neuropathology and these nuclear inclusions points to their possible role in pathogenesis.

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  1. Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, UK

    G P Reynolds & C F Dalton

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  1. G P Reynolds
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  2. C F Dalton
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Reynolds, G., Dalton, C. Transgenic models and subcellular pathology — do they tell us what goes wrong in Huntington's disease?. Mol Psychiatry 3, 192–195 (1998). https://doi.org/10.1038/sj.mp.4000374

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  • DOI: https://doi.org/10.1038/sj.mp.4000374

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