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Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders

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Abstract

We studied tyrosine hydroxylase (TH) gene variants in mood disorders using linkage disequilibrium techniques. One hundred and forty-five inpatients affected by bipolar (n = 88) and unipolar (n = 57) disorders, and 84 healthy controls, were typed for TH variants using polymerase chain reaction (PCR) amplification. TH was associated with mood disorder, with all affected subjects presenting an excess of TH*2 allele (χ2 = 8.30, d.f. = 1; P = 0.004) and lack of the TH*1 allele (χ2 = 6.90, d.f. = 1, P = 0.009). Linkage disequilibrium analyses confirmed the association. Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.

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Authors and Affiliations

  1. Department of Neuroscience, Istituto Scientifico H San Raffaele, University of Milano (Italy) School of Medicine, Milano, Italy

    A Serretti, F Macciardi, C Cusin, M Verga, S Pedrini & E Smeraldi

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  1. A Serretti
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  2. F Macciardi
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  3. C Cusin
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  4. M Verga
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  5. S Pedrini
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  6. E Smeraldi
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Serretti, A., Macciardi, F., Cusin, C. et al. Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders. Mol Psychiatry 3, 169–174 (1998). https://doi.org/10.1038/sj.mp.4000373

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  • DOI: https://doi.org/10.1038/sj.mp.4000373

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