Skip to main content
Log in

A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia

  • Letter to the Editor
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1
Figure 2

Accession codes

Accessions

GenBank/EMBL/DDBJ

References

  1. Slape C, Aplan PD . The role of NUP98 gene fusions in hematologic malignancy. Leuk Lymphoma 2004; 45: 1341–1350.

    Article  CAS  Google Scholar 

  2. Wysocka J, Swigut T, Xiao H, Milne TA, Kwon SY, Landry J et al. A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature 2006; 442: 86–90.

    Article  CAS  Google Scholar 

  3. Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T et al. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature 2006; 442: 96–99.

    Article  CAS  Google Scholar 

  4. Eklund EA . The role of HOX genes in myeloid leukemogenesis. Curr Opin Hematol 2006; 13: 67–73.

    Article  CAS  Google Scholar 

  5. Hussey DJ, Dobrovic A . Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis. Blood 2002; 99: 1097–1098.

    Article  CAS  Google Scholar 

  6. Jaju RJ, Fidler C, Haas OA, Strickson AJ, Watkins F, Clark K et al. A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15*5) in de novo childhood acute myeloid leukemia. Blood 2001; 98: 1264–1267.

    Article  CAS  Google Scholar 

  7. Rosati R, La Starza R, Veronese A, Aventin A, Schwienbacher C, Vallespi T et al. NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15). Blood 2002; 99: 3857–3860.

    Article  CAS  Google Scholar 

  8. Gurevich RM, Aplan PD, Humphries RK . NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation. Blood 2004; 104: 1127–1136.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Y Ning.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reader, J., Meekins, J., Gojo, I. et al. A novel NUP98-PHF23 fusion resulting from a cryptic translocation t(11;17)(p15;p13) in acute myeloid leukemia. Leukemia 21, 842–844 (2007). https://doi.org/10.1038/sj.leu.2404579

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2404579

  • Springer Nature Limited

This article is cited by

Navigation