Skip to main content

Advertisement

SpringerLink
Log in

Prognostic value of Cyclin D2 mRNA expression in newly diagnosed multiple myeloma treated with high-dose chemotherapy and tandem autologous stem cell transplantations

  • Letter to the Editor
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1

Accession codes

Accessions

GenBank/EMBL/DDBJ

References

  1. Barlogie B, Shaughnessy J, Tricot G, Jacobson J, Zangari M, Anaissie E et al. Treatment of multiple myeloma. Blood 2004; 103: 20–32.

    Article  CAS  Google Scholar 

  2. Stewart AK, Fonseca R . Prognostic and therapeutic significance of myeloma genetics and gene expression profiling. J Clin Oncol 2005; 23: 6339–6344.

    Article  CAS  Google Scholar 

  3. Bergsagel P, Kuehl W, Zhan F, Sawyer J, Barlogie B, Shaughnessy J . Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood 2005; 106: 296–303.

    Article  CAS  Google Scholar 

  4. Agnelli L, Bicciato S, Mattioli M, Fabris S, Intini D, Verdelli D et al. Molecular classification of multiple myeloma: a distinct transcriptional profile characterizes patients expressing CCND1 and negative for 14q32 translocations. J Clin Oncol 2005; 23: 7296–7306.

    Article  CAS  Google Scholar 

  5. Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T et al. Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Cancer Cell 2004; 5: 191–199.

    Article  CAS  Google Scholar 

  6. Soverini S, Cavo M, Cellini C, Terragna C, Zamagni E, Ruggeri D et al. Cyclin D1 overexpression is a favorable prognostic variable for newly diagnosed multiple myeloma patients treated with high-dose chemotherapy and single or double autologous transplantation. Blood 2003; 102: 1588–1594.

    Article  CAS  Google Scholar 

  7. Malumbres M, Barbacid M . To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer 2001; 1: 222–231.

    Article  CAS  Google Scholar 

  8. Ely S, Di Liberto M, Niesvizky R, Baughn LB, Cho HJ, Hatada EN et al. Mutually exclusive cyclin-dependent kinase 4/cyclin D1 and cyclin-dependent kinase 6/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma. Cancer Res 2005; 65: 11345–11353.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Donna D and Donald M Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    I Hanamura, Y Huang, F Zhan, B Barlogie & J Shaughnessy Jr

Authors
  1. I Hanamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F Zhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B Barlogie
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J Shaughnessy Jr
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J Shaughnessy Jr.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hanamura, I., Huang, Y., Zhan, F. et al. Prognostic value of Cyclin D2 mRNA expression in newly diagnosed multiple myeloma treated with high-dose chemotherapy and tandem autologous stem cell transplantations. Leukemia 20, 1288–1290 (2006). https://doi.org/10.1038/sj.leu.2404253

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2404253

  • Springer Nature Limited

This article is cited by

Search

Navigation