References
Yang E, Korsmeyer SJ . Molecular thanatopsis: a discourse on the Bcl2 family and cell death. Blood 1996; 88: 386–401.
Deng X, Kornblau SM, Ruvolo PP, May WS . Regulation of Bcl2 phosphorylation and potential significance for leukemic cell chemoresistance. J Natl Cancer Inst 2000; Monograph 28: 30–37.
Haldar S, Jena N, Croce CM . Inactivation of Bcl2 by phosphorylation. Proc Natl Acad Sci USA 1995; 92: 4507–4511.
Ito T, Deng X, Carr BK, May WS . Bcl2 phosphorylation required for anti-apoptosis function. J Biol Chem 1997; 272: 11671–11673.
Ruvolo PP, Deng X, Carr BK, May WS . A functional role for mitochondrial PKC α in Bcl2 phosphorylation and suppression of apoptosis. J Biol Chem 1998; 273: 25436–25442.
Deng X, Ruvolo P, Carr B, May WS . Survival function of ERK1/2 as IL-3-activated staurosporine-resistant Bcl2 kinases. Proc Natl Acad Sci USA 2000; 97: 1578–1583.
Konopleva M, Tsao T, Ruvolo P, Stiouf I, Estrov Z, Leysath CE et al. Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood 2002; 99: 326–335.
Kornblau SM, Vu HT, Ruvolo P, Estrov Z, O'Brien S, Cortes J et al. Bax and PKCα modulate the prognostic impact of Bcl2 expression in acute myelogenous leukemia. Clinical Cancer Res 2000; 6: 1401–1409.
Pagano M, Halvorsen K . An algorithm for finding the exact significance levels of r x c contingency tables. J Am Stat Assoc 1981; 76: 731–934.
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Kurinna, S., Konopleva, M., Palla, S. et al. Bcl2 phosphorylation and active PKC α are associated with poor survival in AML. Leukemia 20, 1316–1319 (2006). https://doi.org/10.1038/sj.leu.2404248
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DOI: https://doi.org/10.1038/sj.leu.2404248
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