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Universal N-glycosylation sites introduced into the B-cell receptor of follicular lymphoma by somatic mutation: a second tumorigenic event?

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References

  1. Zhu D, McCarthy H, Ottensmeier CH, Johnson P, Hamblin TJ, Stevenson FK . Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma. Blood 2002; 99: 2562–2568.

    Article  CAS  PubMed  Google Scholar 

  2. Zhu D, Ottensmeier CH, Du MQ, McCarthy H, Stevenson FK . Incidence of potential glycosylation sites in immunoglobulin variable regions distinguishes between subsets of Burkitt’s lymphoma and mucosa-associated lymphoid tissue lymphoma. Br J Haematol 2003; 120: 217–222.

    Article  CAS  PubMed  Google Scholar 

  3. Bahler DW, Campbell MJ, Hart S, Miller RA, Levy S, Levy R . Ig VH gene expression among human follicular lymphomas. Blood 1991; 78: 1561–1568.

    CAS  PubMed  Google Scholar 

  4. Hsu FJ, Levy R . Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma. Blood 1995; 86: 3072–3082.

    CAS  PubMed  Google Scholar 

  5. Stamatopoulos K, Kosmas C, Papadaki T, Pouliou E, Belessi C, Afendaki S et al. Follicular lymphoma immunoglobulin kappa light chains are affected by the antigen selection process, but to a lesser degree than their partner heavy chains. Br J Haematol 1997; 96: 132–146.

    Article  CAS  PubMed  Google Scholar 

  6. Noppe SM, Heirman C, Bakkus MH, Brissinck J, Schots R, Thielemans K . The genetic variability of the VH genes in follicular lymphoma: the impact of the hypermutation mechanism. Br J Haematol 1999; 107: 625–640.

    Article  CAS  PubMed  Google Scholar 

  7. Aarts WM, Bende RJ, Steenbergen EJ, Kluin PM, Ooms EC, Pals ST et al. Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load. Blood 2000; 95: 2922–2929.

    CAS  PubMed  Google Scholar 

  8. Zabalegui N, de Cerio AL, Inoges S, Rodriguez-Calvillo M, Perez-Calvo J, Hernandez M et al. Acquired potential N-glycosylation sites within the tumor-specific immunoglobulin heavy chains of B-cell malignancies. Haematologica 2004; 89: 541–546.

    CAS  PubMed  Google Scholar 

  9. Kasturi L, Chen H, Shakin-Eshleman SH . Regulation of N-linked core glycosylation: use of a site-directed mutagenesis approach to identify Asn-Xaa-Ser/Thr sequons that are poor oligosaccharide acceptors. Biochem J 1997; 323 (Part 2): 415–419.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Dorner T, Brezinschek HP, Brezinschek RI, Foster SJ, Domiati-Saad R, Lipsky PE . Analysis of the frequency and pattern of somatic mutations within nonproductively rearranged human variable heavy chain genes. J Immunol 1997; 158: 2779–2789.

    CAS  PubMed  Google Scholar 

  11. Foster SJ, Dorner T, Lipsky PE . Targeting and subsequent selection of somatic hypermutations in the human V kappa repertoire. Eur J Immunol 1999; 29: 3122–3132.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was funded by Cancer Research UK and the Nessex Cancer Trust.

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Correspondence to C H Ottensmeier.

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McCann, K., Johnson, P., Stevenson, F. et al. Universal N-glycosylation sites introduced into the B-cell receptor of follicular lymphoma by somatic mutation: a second tumorigenic event?. Leukemia 20, 530–534 (2006). https://doi.org/10.1038/sj.leu.2404095

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