Skip to main content

Advertisement

SpringerLink
Log in

A transgenic mouse model for TEL-JAK2-induced B-cell lymphoma/leukemia

  • Letter to the Editor
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3

References

  1. Lacronique V, Boureux A, Valle VD, Poirel H, Tran Quang C, Mauchauffé M et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 1997; 278: 1309–1312.

    Article  CAS  PubMed  Google Scholar 

  2. Peeters P, Raynaud SD, Cools J, Wlodarska I, Grosgeorge J, Philip P et al. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 1997; 90: 2535–2540.

    CAS  PubMed  Google Scholar 

  3. Griesinger F, Hennig H, Hillmer F, Podleschny M, Steffens R, Pies A et al. A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia. Genes Chromosomes Cancer 2005; 44: 329–333.

    Article  CAS  PubMed  Google Scholar 

  4. Reiter A, Walz C, Watmore A, Schoch C, Blau I, Schlegelberger B et al. The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2. Cancer Res 2005; 65: 2662–2667.

    Article  CAS  PubMed  Google Scholar 

  5. Tefferi A, Gilliland DG . JAK2 in myeloproliferative disorders is not just another kinase. Cell Cycle 2005; 4: 1053–1056.

    Article  CAS  PubMed  Google Scholar 

  6. Carron C, Cormier F, Janin A, Lacronique V, Giovannini M, Daniel M-T et al. TEL-JAK2 transgenic mice develop T-cell leukemia. Blood 2000; 95: 3891–3899.

    CAS  PubMed  Google Scholar 

  7. Schwaller J, Frantsve J, Aster J, Williams IR, Tomasson MH, Ross TS et al. Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes. EMBO J 1998; 17: 5321–5333.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Malissen M, Gillet A, Ardouin L, Bouvier G, Trucy J, Ferrier P et al. Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene. EMBO J 1995; 14: 4641–4653.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We thank Maryvonne Williame for excellent technical assistance, Françoise Cormier for animal expertise and the lab members for helpful discussions. This work was supported by a Marie Curie Fellowship of the European Community program ‘Improving the Human Research Potential and the Socio-Economic knowledge base’ (Contract No. HPMF-CT-2000-00481) (NRdS) and funds from the Centre National de la Recherche Scientifique (CNRS), Institut Curie, Section Recherche, the Association for International Cancer Research (AICR) and the Ligue Nationale contre le Cancer (Équipe labelisée la Ligue).

Author information

Authors and Affiliations

  1. Institut Curie, CNRS UMR 146, Centre Universitaire, Bât. 110, Orsay, 91405, France

    N R dos Santos & J Ghysdael

Authors
  1. N R dos Santos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J Ghysdael
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Santos, N., Ghysdael, J. A transgenic mouse model for TEL-JAK2-induced B-cell lymphoma/leukemia. Leukemia 20, 182–185 (2006). https://doi.org/10.1038/sj.leu.2404026

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2404026

  • Springer Nature Limited

This article is cited by

Search

Navigation