Skip to main content
SpringerLink
Log in

Mcl-1 gene promoter insertions do not correlate with disease outcome, stage or VH gene mutation status in chronic lymphocytic leukaemia

  • Correspondence
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1

References

  1. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK . Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848–1854.

    CAS  PubMed  Google Scholar 

  2. Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood 1999; 94: 1840–1847.

    CAS  PubMed  Google Scholar 

  3. Saxena A, Viswanathan S, Moshynska O, Tandon P, Sankaran K, Sheridan DP . Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia. Am J Hematol 2004; 75: 22–33.

    Article  CAS  Google Scholar 

  4. Kitada S, Andersen J, Akar S, Zapata JM, Takayama S, Krajewski S et al. Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with in vitro and in vivo chemoresponses. Blood 1998; 91: 3379–3389.

    CAS  PubMed  Google Scholar 

  5. Johnston JB, Paul JT, Neufeld NJ, Haney N, Kropp DM, Hu X et al. Role of myeloid cell factor-1 (Mcl-1) in chronic lymphocytic leukemia. Leukemia Lymphoma 2004; 45: 2017–2027.

    Article  CAS  Google Scholar 

  6. Moshynska O, Sankaran K, Pahwa P, Saxena A . Prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia. J Natl Cancer Inst 2004; 96: 673–682.

    Article  CAS  Google Scholar 

  7. Tobin G, Thunberg U, Johnson A, Thorn I, Soderberg O, Hultdin M et al. Somatically mutated Ig V(H)3–21 genes characterize a new subset of chronic lymphocytic leukemia. Blood 2002; 99: 2262–2264.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We are grateful to Drs Lars Klareskog and Leonid Padyukov and to the EIRA group for help with the collection of the normal control material. This study was supported by grants from the Swedish Cancer Society, Lion's Cancer Research Foundation, Uppsala and the research foundation of the Department of Oncology at Uppsala University.

Author information

Author notes

  1. G Tobin and Å Skogsberg: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden

    G Tobin, Å Skogsberg, C Sundström, K Nilsson & R Rosenquist

  2. Department of Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden

    U Thunberg & A Laurell

  3. Department of Medical Sciences, Uppsala University Hospital, Umeå University, Sweden

    A Åleskog

  4. Department of Medicine at Huddinge University Hospital, Umeå University, Sweden

    M Merup

  5. Department of Medical Biosciences, Pathology, Umeå University, Sweden

    G Roos

Authors
  1. G Tobin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Å Skogsberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. U Thunberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Laurell
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A Åleskog
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M Merup
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. C Sundström
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. G Roos
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. K Nilsson
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. R Rosenquist
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G Tobin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tobin, G., Skogsberg, Å., Thunberg, U. et al. Mcl-1 gene promoter insertions do not correlate with disease outcome, stage or VH gene mutation status in chronic lymphocytic leukaemia. Leukemia 19, 871–873 (2005). https://doi.org/10.1038/sj.leu.2403715

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403715

  • Springer Nature Limited

This article is cited by

Search

Navigation