Skip to main content

Advertisement

SpringerLink
Log in

Molecular and cytogenetic characterization of a new case of t(5;17)(q35;q21) variant acute promyelocytic leukemia

  • Correspondence
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2

References

  1. Grimwade D, Biondi A, Mozziconacci MJ, Hagemeijer A, Berger R, Neat M et al. Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): Results of the European Working Party. Groupe Français de Cytogénétique Hematologique, Gruope de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action ‘Molecular Cytogenetic Diagnosis in Haematological Malignancies’. Blood 2000; 96: 1297–1308.

    CAS  PubMed  Google Scholar 

  2. Xu L, Zhao WL, Xiong SM, Su XY, Zhao M, Wang C et al. Molecular cytogenetic characterization and clinical relevance of additional, complex and/or variant chromosome abnormalities in acute promyelocytic leukemia. Leukemia 2001; 15: 1359–1368.

    Article  CAS  PubMed  Google Scholar 

  3. Corey SJ, Locker J, Oliveri DR, Shekhter-Levin S, Redner RL, Penchasky L et al. A non-classical translocation involving 17q12 (retinoic acid receptor alpha) in acute promyelocytic leukemia (APL) with atypical features. Leukemia 1994; 8: 1350–1353.

    CAS  PubMed  Google Scholar 

  4. Redner RL, Corey SJ, Rush EA . Differentiation of t(5;17) variant acute promyelocytic leukemia blasts by all-trans retinoic acid. Leukemia 1997; 11: 1014–1016.

    Article  CAS  PubMed  Google Scholar 

  5. Redner RL, Rush EA, Faas S, Rudert WA, Corey SJ . The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin–retinoic acid receptor fusion. Blood 1996; 87: 882.

    CAS  PubMed  Google Scholar 

  6. Redner RL . Variations on a theme: the alternate translocations in APL. Leukemia 2002; 16: 1927–1932.

    Article  CAS  PubMed  Google Scholar 

  7. Redner RL, Chen JD, Rush EA, Li H, Pollock SL . The t(5;17) acute promyelocytic leukemia fusion protein NPM-RAR interacts with co-repressor and co-activator proteins and exhibits both positive and negative transcriptional properties. Blood 2000; 95: 2683–2690.

    CAS  PubMed  Google Scholar 

  8. Hummel JL, Wells RA, Dube ID, Licht JD, Kamel-Reid S . Deregulation of NPM and PLZF in a variant t(5;17) case of acute promyelocytic leukemia. Oncogene 1999; 18: 633–641.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by the University of Bologna (ex-60% RFO), by Fondazione del Monte di Bologna e Ravenna and by COFIN 2003.

Author information

Authors and Affiliations

  1. Institute of Hematology and Medical Oncology ‘Lorenzo e Ariosto Seràgnoli’, University of Bologna, Bologna, Italy

    C Nicci, E Ottaviani, S Luatti, T Grafone, M Tonelli, M R Motta, M Malagola, G Marzocchi, G Martinelli, M Baccarani & N Testoni

Authors
  1. C Nicci
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E Ottaviani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S Luatti
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T Grafone
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M Tonelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M R Motta
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M Malagola
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. G Marzocchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. G Martinelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M Baccarani
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. N Testoni
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to N Testoni.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nicci, C., Ottaviani, E., Luatti, S. et al. Molecular and cytogenetic characterization of a new case of t(5;17)(q35;q21) variant acute promyelocytic leukemia. Leukemia 19, 470–472 (2005). https://doi.org/10.1038/sj.leu.2403645

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403645

  • Springer Nature Limited

This article is cited by

Search

Navigation