Skip to main content

Advertisement

Log in

High incidence of trisomies 1q, 9q, and 11q in multiple myeloma: results from a comprehensive molecular cytogenetic analysis

  • Correspondence
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1

References

  1. Avet-Loiseau H, Facon T, Grosbois B, Magrangeas F, Rapp MJ, Harousseau JL et al. Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation. Blood 2002; 99: 2185–2191.

    Article  CAS  Google Scholar 

  2. Fonseca R, Blood E, Rue M, Harrington D, Oken MM, Kyle RA et al. Clinical and biologic implications of recurrent genomic aberrations in myeloma. Blood 2003; 101: 4569–4575.

    Article  CAS  Google Scholar 

  3. Liebisch P, Viardot A, Baßermann N, Wendl C, Roth K, Goldschmidt H et al. Value of comparative genomic hybridization (CGH) and fluorescence in-situ hybridization (FISH) for molecular diagnostics in multiple myeloma. Br J Haematol 122: 193–201.

  4. Döhner H, Stilgenbauer S, Benner A, Leupolt E, Kröber A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910–1916.

    Article  Google Scholar 

  5. Dascalescu CM, Callanan M, Chauvet M, Le Baccon P, Pegourie-Bandelier B, Garban F et al. Interphase FISH: a rapid method for detecting malignant plasma cells in multiple myeloma patients submitted to autologous transplantation. Bone Marrow Transplant 1999; 23: 687–694.

    Article  CAS  Google Scholar 

  6. Tricot G, Sawyer JR, Jagannath S, Desikan KR, Siegel D, Naucke S et al. Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants. J Clin Oncol 1997; 15: 2659–2666.

    Article  CAS  Google Scholar 

  7. Perez-Simon JA, Garcia-Sanz R, Tabernero MD, Almeida J, Gonzalez M, Fernandez-Calvo J et al. Prognostic value of numerical chromosome aberrations in multiple myeloma: a FISH analysis of 15 different chromosomes. Blood 1998; 91: 3366–3371.

    CAS  Google Scholar 

  8. Königsberg R, Zojer N, Ackermann J, Krömer E, Kittler H, Fritz E et al. Predictive role of interphase cytogenetics for survival of patients with multiple myeloma. J Clin Oncol 2000; 18: 804–812.

    Article  Google Scholar 

Download references

Acknowledgements

This study was supported by a grant from the Deutsche Krebshilfe to PL (70-3899-Li I). We gratefully acknowledge the centers of the Deutsche Studiengruppe Multiples Myelom and the German-Speaking Myeloma Multicenter Group for their continuous support as well as Katrin Roth and Sibylle Janczik for excellent technical assistance.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liebisch, P., Wendl, C., Wellmann, A. et al. High incidence of trisomies 1q, 9q, and 11q in multiple myeloma: results from a comprehensive molecular cytogenetic analysis. Leukemia 17, 2535–2537 (2003). https://doi.org/10.1038/sj.leu.2403153

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2403153

  • Springer Nature Limited

This article is cited by

Navigation