Skip to main content

Advertisement

SpringerLink
Log in

Contrary to adult patients, expression of the multidrug resistance gene (MDR1) fails to define a poor prognostic group in childhood AML

  • Correspondence
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2

References

  1. Marie JP. Drug resistance in hematologic malignancies. Curr Opin Oncol 2001). 13, 463–469.

    Article  CAS  Google Scholar 

  2. List AF, Kopecky KJ, Willman CL, Head DR, Persons DL, Slovak ML, Dorr R, Karanes C, Hynes HE, Doroshow JH, Shurafa M & Appelbaum FR . Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study. Blood 2001; 98: 3212–3220.

    Article  CAS  Google Scholar 

  3. Steinbach D, Sell W, Voigt A, Hermann J, Zintl F & Sauerbrey A . BCRP gene expression is associated with a poor response to remission induction therapy in childhood acute myeloid leukemia. Leukemia 2002; 16: 1443–1447.

    Article  CAS  Google Scholar 

  4. Schiedlmeier B, Kuhlcke K, Eckert HG, Baum C, Zeller WJ & Fruehauf S . Quantitative assessment of retroviral transfer of the human multidrug resistance 1 gene to human mobilized peripheral blood progenitor cells engrafted in nonobese diabetic/severe combined immunodeficient mice. Blood 2000; 95: 1237–1248.

    CAS  PubMed  Google Scholar 

  5. Yamada S, Hongo T, Okada S, Watanabe C, Fujii Y & Ohzeki T . Clinical relevance of in vitro chemoresistance in childhood acute myeloid leukemia. Leukemia 2001; 15: 1892–1897.

    Article  CAS  Google Scholar 

  6. Sievers EL, Smith FO, Woods WG, Lee JW, Bleyer WA, Willman CL & Bernstein ID . Cell surface expression of the multidrug resistance P-glycoprotein (P-170) as detected by monoclonal antibody MRK-16 in pediatric acute myeloid leukemia fails to define a poor prognostic group: a report from the Childrens Cancer Group. Leukemia 1995; 9: 2042–2048.

    CAS  Google Scholar 

  7. Dahl GV, Lacayo NJ, Brophy N, Dunussi-Joannopoulos K, Weinstein HJ, Chang M, Sikic BI & Arceci RJ . Mitoxantrone, etoposide, and cyclosporine therapy in pediatric patients with recurrent or refractory acute myeloid leukemia. J Clin Oncol 2000; 18: 1867–1875.

    Article  CAS  Google Scholar 

  8. Pearson L, Leith CP, Duncan MH, Chen IM, McConnell T, Trinkaus K, Foucar K & Willman CL . Multidrug resistance-1 (MDR1) expression and functional dye/drug efflux is highly correlated with the t(8; 21) chromosomal translocation in pediatric acute myeloid leukemia. Leukemia 1996; 10: 1274–1282.

    CAS  PubMed  Google Scholar 

  9. den Boer ML, Pieters R, Kazemier KM, Rottier MM, Zwaan CM, Kaspers GJ, Janka-Schaub G, Henze G, Creutzig U, Scheper RJ & Veerman AJ . Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia. Blood 1998; 91: 2092–2098.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. University Children’s Hospital, Jena, Germany

    D Steinbach, S Furchtbar, W Sell, J Lengemann, J Hermann, F Zintl & A Sauerbrey

Authors
  1. D Steinbach
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S Furchtbar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. W Sell
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J Lengemann
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J Hermann
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F Zintl
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A Sauerbrey
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Steinbach, D., Furchtbar, S., Sell, W. et al. Contrary to adult patients, expression of the multidrug resistance gene (MDR1) fails to define a poor prognostic group in childhood AML. Leukemia 17, 470–471 (2003). https://doi.org/10.1038/sj.leu.2402806

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2402806

  • Springer Nature Limited

This article is cited by

Search

Navigation