Abstract
The discovery of the Philadelphia chromosome and its consistent involvement in chronic myeloid leukemia (CML) was the first time that a relationship between a cytogenetic abnormality and malignancy was demonstrated. This review will try to provide an insight into the molecular mechanisms underlying this disease and outline the therapeutical options for patients with CML.
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Thijsen, S., Schuurhuis, G., van Oostveen, J. et al. Chronic myeloid leukemia from basics to bedside. Leukemia 13, 1646–1674 (1999). https://doi.org/10.1038/sj.leu.2401565
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DOI: https://doi.org/10.1038/sj.leu.2401565
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