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Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection

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Abstract

Objectives:

To investigate postnatal lipopolysaccharide-binding protein (LBP) kinetics in term neonates and to test its diagnostic accuracy for early-onset bacterial infection (EOBI).

Study design:

A total of 99 neonates with clinical and serological signs of EOBI comprised the study group; 198 neonates with risk factors, but without EOBI, served as controls. LBP, C-reactive protein (CRP) and interleukin-8 (IL-8) were determined.

Results:

LBP in the noninfected group increased until 24 h after birth (P<0.05 vs 6 h). LBP and CRP correlated strongly in neonates with suspected EOBI (r=0.63). Although LBP reached a higher sensitivity than CRP 6 and 12 h after clinical suspicion (45 (24–68) and 79% (54–94) vs 9 (0–24) and 39% (17–64); P<0.05)), EOBI was most reliably detected by IL-8.

Conclusion:

LBP kinetics were age-dependent. LBP was not sufficiently sensitive in the prediction of EOBI.

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Authors and Affiliations

  1. Department of Neonatology, University Children's Hospital, Tübingen, Germany

    T W Orlikowsky, C Trüg, F Neunhoeffer & C F Poets

  2. Department of Surgery, Loretto Hospital, Freiburg, Germany

    C Trüg

  3. University Women's Hospital, Tübingen, Germany

    M Deperschmidt

  4. Department of Medical Biometry, Tübingen, Germany

    M Eichner

Authors
  1. T W Orlikowsky
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  2. C Trüg
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  3. F Neunhoeffer
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  4. M Deperschmidt
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  5. M Eichner
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  6. C F Poets
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Correspondence to C F Poets.

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Orlikowsky, T., Trüg, C., Neunhoeffer, F. et al. Lipopolysaccharide-binding protein in noninfected neonates and those with suspected early-onset bacterial infection. J Perinatol 26, 115–119 (2006). https://doi.org/10.1038/sj.jp.7211422

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  • DOI: https://doi.org/10.1038/sj.jp.7211422

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