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Clinical Perinatal/Neonatal Case Presentation

Candida Chorioamnionitis After Serial Therapeutic Amniocenteses: A Possible Association

  • Clinical/Perinatal Neonatal Case Presentation
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Abstract

BACKGROUND: Reduction amniocentesis is used in cases of severe polyhydramnios to decrease maternal discomfort and the risk of preterm labor. In a MEDLINE search (1966 to present, English language, keywords: amniocentesis, chorioamnionitis), no report of Candida chorioamnionitis after serial reduction amniocentesis exists.

CASE:

A 29-year-old primigravida with a history of four therapeutic amniocenteses for idiopathic polyhydramnios developed preterm labor at 30 and 5/7 weeks’ gestation, rupture of membranes, and Candida albicans chorioamnionitis. Despite aggressive therapy with amphotericin B, the neonate succumbed to overwhelming systemic candidiasis.

CONCLUSION: Serial amniocentesis may place patients at elevated risk for Candida chorioamnionitis and subsequent preterm delivery. Clinicians should consider early diagnostic amniocentesis in patients in preterm labor with a history of prior amniocentesis, and the routine Gram stain and culture of amniotic fluid.

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Authors and Affiliations

  1. Division of Maternal-Fetal Medicine (M. E. R., Department of Obstetrics and Gynecology, M. A. M., I. F.), The University of Pennsylvania Health System, Philadelphia, PA

    Martha E Rode MD, Mark A Morgan MD & Iraj Forouzan MD

  2. Department of Pathology (E. R.), The Children’s Hospital of Philadelphia, Philadelphia, PA

    Eduardo Ruchelli MD

Authors
  1. Martha E Rode MD
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  2. Mark A Morgan MD
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  3. Eduardo Ruchelli MD
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  4. Iraj Forouzan MD
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Correspondence to Martha E Rode MD.

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Rode, M., Morgan, M., Ruchelli, E. et al. Candida Chorioamnionitis After Serial Therapeutic Amniocenteses: A Possible Association. J Perinatol 20, 335–337 (2000). https://doi.org/10.1038/sj.jp.7200381

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  • DOI: https://doi.org/10.1038/sj.jp.7200381

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