The effect of glucose concentration on erythritol production by Torula sp. was investigated. The maximum volumetric productivity of erythritol was obtained at an initial glucose concentration of 300 g l−1 in batch culture. The volumetric productivity was maximal at a controlled glucose concentration of 225 g l−1, reducing the lag time of the erythritol production. A fed-batch culture was established with an initial glucose concentration of 300 g l−1 and with a controlled glucose concentration of 225 g l−1 in medium containing phytic acid as a phosphate source. In this fed-batch culture, a final erythritol production of 192 g l−1 was obtained from 400 g l−1 glucose in 88 h. This corresponded to a volumetric productivity of 2.26 g l−1 h−1 and a 48% yield. Journal of Industrial Microbiology & Biotechnology (2001) 26, 248–252.
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Received 26 September 2000/ Accepted in revised form 16 January 2001
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Oh, DK., Cho, CH., Lee, JK. et al. Increased erythritol production in fed-batch cultures of Torula sp. by controlling glucose concentration. J Ind Microbiol Biotech 26, 248–252 (2001). https://doi.org/10.1038/sj.jim.7000122
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DOI: https://doi.org/10.1038/sj.jim.7000122