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Genetic engineering of doxorubicin production in Streptomyces peucetius: a review

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Journal of Industrial Microbiology and Biotechnology

The genetics and biochemistry of daunorubicin and doxorubicin production by Streptomyces peucetius is reviewed, with a focus on how such information can be used for the genetic engineering of strains having improved titers of these two antitumor antibiotics.

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Authors and Affiliations

  1. School of Pharmacy and Department of Bacteriology, University of Wisconsin, Madison 53706, USA, , , , , , US

    C R Hutchinson

  2. Global Supply/CFO/API, Pharmacia and Upjohn, 20014 Nerviano, Milan, Italy, , , , , , IT

    A L Colombo

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  1. C R Hutchinson
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  2. A L Colombo
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Received 23 February 1999/ Accepted in revised form 22 March 1999

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Hutchinson, C., Colombo, A. Genetic engineering of doxorubicin production in Streptomyces peucetius: a review. J Ind Microbiol Biotech 23, 647–652 (1999). https://doi.org/10.1038/sj.jim.2900673

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  • DOI: https://doi.org/10.1038/sj.jim.2900673

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