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Lack of association between a human β-2 adrenoceptor gene polymorphism (gln27glu) and morbid obesity

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Abstract

OBJECTIVE: To determine the frequency of the gln27glu polymorphism in the β-2 adrenoceptor gene in patients with morbid obesity.

SUBJECTS: 243 patients with morbid obesity (mean body mass index 51.6) and 199 healthy blood donors.

RESULTS: The same frequency, 0.42, of the glu allele was observed in both groups. Neither the incidence in obese women (0.41, n=197) compared to control women (0.43, n=61), nor that in obese men (0.44, n=46) compared to control men (0.41, n=138) was significantly different. The difference in frequency between obese men and women, 0.44 vs 0.41 was not significant (P=0.68). Genotype information from the families of 18 of the obese patients showed no association between the glu27 allele and BMI.

CONCLUSIONS: We find no evidence for a role of the glu27 variant in the β-2 adrenoceptor gene in the development of morbid obesity.

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Authors and Affiliations

  1. Klinik für Allgemeinchirurgie, Evangelisches und Johanniter Klinikum, Dinslaken, Germany

    B Kortner & A Wolf

  2. Medizinische Klinik, Universitätskrankenhaus Eppendorf, Hamburg, Germany

    D Wendt, U Beisiegel & D Evans

Authors
  1. B Kortner
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  2. A Wolf
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  3. D Wendt
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  4. U Beisiegel
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  5. D Evans
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Correspondence to D Evans.

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Kortner, B., Wolf, A., Wendt, D. et al. Lack of association between a human β-2 adrenoceptor gene polymorphism (gln27glu) and morbid obesity. Int J Obes 23, 1099–1100 (1999). https://doi.org/10.1038/sj.ijo.0801063

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  • DOI: https://doi.org/10.1038/sj.ijo.0801063

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