Abstract
OBJECTIVE: To determine whether a microsatellite polymorphism located towards the 3’ end of the low density lipoprotein receptor gene (LDLR) is associated with obesity. DESIGN: A cross-sectional case-control study. SUBJECTS: One hundred and seven obese individuals, defined as a body mass index (BMI)≥26 kg/m2, and 163 lean individuals, defined as a BMI<26 kg/m2. MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp). RESULTS: There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (χ2=12.3, P=0.002), but not in males (χ2=0.3, P=0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese. CONCLUSIONS: These results suggest that in females, LDLR may play a role in the development of obesity.
Similar content being viewed by others
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rutherford, S., Nyholt, D., Curtain, R. et al. Association of a low density lipoprotein receptor microsatellite variant with obesity. Int J Obes 21, 1032–1037 (1997). https://doi.org/10.1038/sj.ijo.0800512
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.ijo.0800512
- Springer Nature Limited
Keywords
This article is cited by
-
The Human Obesity Gene Map: The 2004 Update
Obesity Research (2005)
-
The Human Obesity Gene Map: The 2002 Update
Obesity Research (2003)
-
The Human Obesity Gene Map: The 2001 Update
Obesity Research (2002)
-
The Human Obesity Gene Map: The 2000 Update
Obesity Research (2001)
-
The Human Obesity Gene Map: The 1999 Update
Obesity Research (2000)