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Trp64Arg substitution in the β3-adrenergic receptor does not relate to body weight in healthy, premenopausal women

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Abstract

OBJECTIVE: To examine the contribution of the substitution of arginine for tryptophan at amino acid position 64 (Trp64Arg) of the β3-adrenergic receptor to body weight and weight-related factors in healthy, premenopausal women. SUBJECTS: Five hundred and five healthy, premenopausal women 44–50 y, body mass index (BMI) 20–34 kg/m2. MEASUREMENTS: Subjects were genotyped for the Trp64Arg substitution using restriction fragment length polymorphism (RFLP) analysis. Measurements for weight and weight-related factors (for example, weight, waist-hip ratio, lipid levels) were also taken. RESULTS: Two women were homozygous Arg/Arg, 75 women were heterozygous Trp/Arg, and 428 women were homozygous Trp/Trp. The frequency of the Arg substitution was 0.078. When subjects with and without the arginine substitution were compared, no significant differences were found on measures of weight or weight-related risk factors. CONCLUSION: The results confirm previous studies suggesting that the Trp64Arg substitution of the β3-adrenergic receptor is not related to weight or weight-related phenotypes in healthy, premenopausal women.

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Authors and Affiliations

  1. Department of Human Genetics, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, 15213, PA, USA

    M Moriarty & RE Ferrell

  2. Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, 15213, PA, USA

    RR Wing & LH Kuller

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  1. M Moriarty
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  2. RR Wing
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  3. LH Kuller
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  4. RE Ferrell
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Moriarty, M., Wing, R., Kuller, L. et al. Trp64Arg substitution in the β3-adrenergic receptor does not relate to body weight in healthy, premenopausal women. Int J Obes 21, 826–829 (1997). https://doi.org/10.1038/sj.ijo.0800489

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  • DOI: https://doi.org/10.1038/sj.ijo.0800489

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