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Increased spontaneous, tumor necrosis factor receptor- and CD95 (Fas)-mediated apoptosis in cord blood T-cell subsets from Turner's syndrome

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Abstract

Increased spontaneous as well as TNF-α-induced and CD95-mediated apoptosis were observed in CD4+ and CD8+ T cells from the cord blood of a patient with Turner's syndrome as compared to normal cord blood. Increased apoptosis was associated with an increased expression of TNFR-1, TNFR-2, and CD95L and decreased expression of cIAP1 and FLIPL. No significant difference was observed in the expression of Bcl-2 family members (Bcl-2, Bax) between Turner's syndrome cord blood and normal cord blood lymphocytes. This study demonstrates that increased apoptosis of T-cell subsets in Turner's syndrome occurs via the death receptor pathway and may play a role in the pathogenesis of immunological defects associated with Turner's syndrome.

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Authors and Affiliations

  1. Division of Basic and Clinical Immunology, Cellular and Molecular Immunology Laboratories, University of California, Irvine, CA, USA

    S Gupta, S Chiplunkar, A Gupta & S Gollapudi

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  1. S Gupta
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  2. S Chiplunkar
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  3. A Gupta
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  4. S Gollapudi
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Correspondence to S Gupta.

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Gupta, S., Chiplunkar, S., Gupta, A. et al. Increased spontaneous, tumor necrosis factor receptor- and CD95 (Fas)-mediated apoptosis in cord blood T-cell subsets from Turner's syndrome. Genes Immun 4, 239–243 (2003). https://doi.org/10.1038/sj.gene.6363945

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