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A novel polymorphism in the pseudogene TCRBV5S5 combines with TCRBV6S1 to define three haplotypes

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Abstract

In the current study, we report a G to A single nucleotide polymorphism at base pair 396 of the TCRBV5S5P gene. This polymorphism has a frequency of 0.20 in a cohort of Caucasian controls. In addition, we provide evidence for linkage disequilibrium between TCRBV5S5P and the TCRBV6S1 gene.

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Acknowledgements

The authors wish to thank Mehdi Keddache from the Department of Pediatrics, Division of Human Genetics, Children’s Hospital Research Foundation of Cincinnati for assistance with the EH software analysis.

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Authors and Affiliations

  1. Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    JL Brzezinski & E Choi

  2. Department of Pediatrics, William S. Rowe Division of Rheumatology, Children’s Hospital Medical Center, Cincinnati, OH, USA

    DN Glass

Authors
  1. JL Brzezinski
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  2. DN Glass
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  3. E Choi
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Corresponding author

Correspondence to E Choi.

Additional information

This work was supported, in part, by National Institutes of Health grants AR44059 and AR44566, the Schmidlapp Foundation, and the Children’s Hospital Research Foundation of Cincinnati

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Brzezinski, J., Glass, D. & Choi, E. A novel polymorphism in the pseudogene TCRBV5S5 combines with TCRBV6S1 to define three haplotypes . Genes Immun 2, 290–291 (2001). https://doi.org/10.1038/sj.gene.6363748

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  • DOI: https://doi.org/10.1038/sj.gene.6363748

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